Cadherin-15 / CDH15 Recombinant Protein | CDH15 recombinant protein

Recombinant Rat Cadherin-15 / CDH15 Protein (Fc tag)

Cat. Num. AAA2547373

• Purity: > 87 % as determined by SDS-PAGE
• Synonyms: Cadherin-15 / CDH15; Recombinant Rat Cadherin-15 / CDH15 Protein (Fc tag); CDH15; CDH15 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: > 87 % as determined by SDS-PAGE
• Form/Format: Liquid; Supplied as sterile PBS, pH 7.4.
• Concentration: 0.91mg/ml (varies by lot)
• Sequence Positions: Met1-Gly602

• Species: Rat
• Tag: C-Fc
• Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method.
• Preparation and Storage: Ships on blue ice.; Store it under sterile conditions at -20 to -80°C upon receiving.; Recommended to aliquot the protein into smaller quantities for optimal storage.

SDS-PAGE

Related Product Information for CDH15 recombinant protein

Cadherin-15, also known as CDH15, is a member of the cadherin superfamily. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell type s. Cadherin-15 contains 5 cadherin domains. It is expressed in some normal epithelial tissues and in some carcinoma cell lines. Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM), also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.

Description: A DNA sequence encoding the rat CDH15 (Q75NI5) (Met1-Gly602) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 46485501
• NCBI GeneID: 361432
• NCBI Accession #: NP_997496.1
• NCBI GenBank Nucleotide #: NM_207613.1
• UniProt Accession #: Q75NI5; F1LQ16
• Molecular Weight: Mol_Mass: 90.6 kDa; AP_Mol_Mass: 118 kDa
• NCBI Official Full Name: cadherin-15
• NCBI Official Synonym Full Names: cadherin 15
• NCBI Official Symbol: Cdh15
• NCBI Protein Information: cadherin-15
• UniProt Protein Name: Cadherin 15
• Protein Family: Cadherin
• UniProt Gene Name: Cdh15

NCBI Description

mouse homolog may play a role in muscle differentiation [RGD, Feb 2006]

Uniprot Description

CDH15: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q12

Cellular Component: caveola; neuromuscular junction