SDS-PAGE
Cadherin-8 / CDH8 Recombinant Protein | CDH8 recombinant protein
Recombinant Rat Cadherin-8 / CDH8 Protein (His tag)
Purity
> 85 % as determined by SDS-PAGE
Synonyms
Cadherin-8 / CDH8; Recombinant Rat Cadherin-8 / CDH8 Protein (His tag); CDH8; CDH8 recombinant protein
Host
Human Cells
Purity/Purification
> 85 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
799
Application Notes
The recombinant rat CDH8 comprises 603 amino acids and predicts a molecular mass of 66.5 kDa. The apparent molecular mass of the recombinant protein is approximately 75-85 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Ala 30
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CDH8 recombinant protein
Background: Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin 8, also known as CDH 8, is a type I I classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type I transmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.
Description: A DNA sequence encoding the rat CDH8 (NP_445845.2) (Met1-Met621) was expressed with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the rat CDH8 (NP_445845.2) (Met1-Met621) was expressed with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
58,973 Da
NCBI Official Full Name
cadherin-8
NCBI Official Synonym Full Names
cadherin 8
NCBI Official Symbol
Cdh8
NCBI Protein Information
cadherin-8
UniProt Protein Name
Cadherin-8
Protein Family
UniProt Gene Name
Cdh8
NCBI Description
may play a role in cell-cell adhesion during spermatogenesis [RGD, Feb 2006]
Uniprot Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Research Articles on CDH8
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Product Notes
The CDH8 cdh8 (Catalog #AAA2547376) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat CDH8 comprises 603 amino acids and predicts a molecular mass of 66.5 kDa. The apparent molecular mass of the recombinant protein is approximately 75-85 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the CDH8 cdh8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cadherin-8 / CDH8, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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