Tgfbr1 blocking peptide

Mouse Tgfbr1 Antibody (Center) Blocking Peptide

• Gene Names: Tgfbr1; ALK5; ESK2; Alk-5; TGFR-1; TbetaRI; AU017191; TbetaR-I
• Synonyms: Tgfbr1; Mouse Tgfbr1 Antibody (Center) Blocking Peptide; TGF-beta receptor type-1; TGFR-1; ESK2; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I; Tgfbr1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 503

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Tgfbr1 blocking peptide

Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 6094468
• NCBI GeneID: 21812
• UniProt Accession #: Q64729; A2AJN0
• Molecular Weight: 55,790 Da
• NCBI Official Full Name: TGF-beta receptor type-1
• NCBI Official Synonym Full Names: transforming growth factor, beta receptor I
• NCBI Official Symbol: Tgfbr1
• NCBI Official Synonym Symbols: ALK5; ESK2; Alk-5; TGFR-1; TbetaRI; AU017191; TbetaR-I
• NCBI Protein Information: TGF-beta receptor type-1
• UniProt Protein Name: TGF-beta receptor type-1
• Protein Family: TGF-beta receptor
• UniProt Gene Name: Tgfbr1
• UniProt Synonym Gene Names: TGFR-1; TGF-beta receptor type I; TbetaR-I
• UniProt Entry Name: TGFR1_MOUSE

NCBI Description

This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Description

TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Receptor, misc.; Kinase, protein; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; cell surface; endosome; lipid raft; plasma membrane; protein complex; receptor complex; tight junction

Molecular Function: ATP binding; growth factor binding; protein binding; protein complex binding; protein heterodimerization activity; protein kinase activity; protein serine/threonine kinase activity; punt binding; receptor binding; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I; ubiquitin protein ligase binding

Biological Process: activation of MAPKK activity; angiogenesis; anterior/posterior pattern formation; artery morphogenesis; blastocyst development; cell motility involved in cell locomotion; collagen fibril organization; embryonic cranial skeleton morphogenesis; embryonic development; endothelial cell migration; epithelial to mesenchymal transition; germ cell migration; heart development; in utero embryonic development; kidney development; lens development in camera-type eye; male gonad development; negative regulation of apoptosis; negative regulation of chondrocyte differentiation; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell proliferation; neuron fate commitment; palate development; parathyroid gland development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of filopodium formation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription, DNA-dependent; post-embryonic development; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of gene expression; regulation of protein binding; regulation of protein ubiquitination; regulation of transcription, DNA-dependent; response to estrogen stimulus; signal transduction; skeletal development; skeletal morphogenesis; thymus development; transforming growth factor beta receptor signaling pathway