LPXN blocking peptide

LPXN Antibody (Center) Blocking Peptide

• Gene Names: LPXN; LDPL
• Synonyms: LPXN; LPXN Antibody (Center) Blocking Peptide; Leupaxin; LDLP; LPXN blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 386

• Cellular Location: Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note: Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin
• Tissue Location: Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LPXN blocking peptide

Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 8134557
• NCBI GeneID: 9404
• UniProt Accession #: O60711; Q53FW6; Q6FI07; B2R8B4; B4DV71
• Molecular Weight: 43,750 Da
• NCBI Official Full Name: Leupaxin
• NCBI Official Synonym Full Names: leupaxin
• NCBI Official Symbol: LPXN
• NCBI Official Synonym Symbols: LDPL
• NCBI Protein Information: leupaxin
• UniProt Protein Name: Leupaxin
• Protein Family: Leupaxin
• UniProt Gene Name: LPXN
• UniProt Synonym Gene Names: LDLP
• UniProt Entry Name: LPXN_HUMAN

NCBI Description

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Uniprot Description

leupaxin: a LIM domain-containing cytoplasmic protein preferentially expressed in hematopoietic cells. Homologous to the focal adhesion protein, paxillin. Associates with PYK2, a member of focal adhesion kinase family, it may participate in signaling at sites of adhesion. .

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: cytoplasm; focal adhesion; membrane; nucleus; plasma membrane; podosome

Molecular Function: protein binding; transcription cofactor activity

Biological Process: negative regulation of B cell receptor signaling pathway; negative regulation of cell adhesion; protein complex assembly; signal transduction