Western Blot (WB)
(LPXN Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the LPXN antibody detected the LPXN protein (arrow).)
Rabbit anti-Human, mouse LPXN Polyclonal Antibody | anti-LPXN antibody
LPXN Antibody (Center)
Western Blot (WB)
(LPXN Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the LPXN antibody detected the LPXN protein (arrow).)
Western Blot (WB)
(LPXN Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the LPXN antibody detected the LPXN protein (arrow).)
Western Blot (WB)
(Western blot analysis of LPXN (arrow) using rabbit polyclonal LPXN Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the LPXN gene.)
Western Blot (WB)
(Western blot analysis of LPXN (arrow) using rabbit polyclonal LPXN Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the LPXN gene.)
expressed in hematopoietic cells and belongs to the paxillin
protein family. Similar to other members of this
focal-adhesion-associated adaptor-protein family, it has four
leucine-rich LD-motifs in the N-terminus and four LIM domains in
the C-terminus. It may function in cell type-specific signaling by
associating with PYK2, a member of focal adhesion kinase family. As
a substrate for a tyrosine kinase in lymphoid cells, this protein
may also function in, and be regulated by, tyrosine kinase
activity. Alternative splicing results in multiple transcript
variants encoding distinct isoforms.
Tanaka, T., et al. Cancer Sci. 101(2):363-368(2010)
Dai, H.P., et al. Genes Chromosomes Cancer 48(12):1027-1036(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Sundberg-Smith, L.J., et al. Circ. Res. 102(12):1502-1511(2008)
NCBI and Uniprot Product Information
NCBI Description
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Uniprot Description
leupaxin: a LIM domain-containing cytoplasmic protein preferentially expressed in hematopoietic cells. Homologous to the focal adhesion protein, paxillin. Associates with PYK2, a member of focal adhesion kinase family, it may participate in signaling at sites of adhesion. .
Protein type: Cytoskeletal; Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: cell projection; focal adhesion; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; podosome; nucleus
Molecular Function: protein binding; zinc ion binding; transcription cofactor activity
Biological Process: regulation of cell adhesion mediated by integrin; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of B cell receptor signaling pathway; protein complex assembly; negative regulation of cell adhesion; cell adhesion; signal transduction
Research Articles on LPXN
Similar Products
Product Notes
The LPXN lpxn (Catalog #AAA9202297) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 229-257. The LPXN Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LPXN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the LPXN lpxn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LPXN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
