Rabbit LPXN Polyclonal Antibody | anti-LPXN antibody

LPXN Rabbit Polyclonal

Cat. Num. AAA7601070

• Gene Names: LPXN; LDPL
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: LPXN; Polyclonal Antibody; LPXN Rabbit Polyclonal; anti-LPXN antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 366

• Applicable Applications for anti-LPXN antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Leupaxin
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer slide using MBS7601070 (LPXN Antibody) at dilution of 1:50)

Western Blot (WB)

(PC-3 cells were subjected to SDS PAGE followed by western blot with MBS7601070 (LPXN Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 808154257
• NCBI GeneID: 9404
• NCBI Accession #: NP_001294880.1
• NCBI GenBank Nucleotide #: NM_001307951.1
• Molecular Weight: 43,750 Da
• NCBI Official Full Name: leupaxin isoform 3
• NCBI Official Synonym Full Names: leupaxin
• NCBI Official Symbol: LPXN
• NCBI Official Synonym Symbols: LDPL
• NCBI Protein Information: leupaxin
• UniProt Protein Name: Leupaxin
• Protein Family: Leupaxin
• UniProt Gene Name: LPXN
• UniProt Synonym Gene Names: LDLP
• UniProt Entry Name: LPXN_HUMAN

NCBI Description

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Uniprot Description

leupaxin: a LIM domain-containing cytoplasmic protein preferentially expressed in hematopoietic cells. Homologous to the focal adhesion protein, paxillin. Associates with PYK2, a member of focal adhesion kinase family, it may participate in signaling at sites of adhesion. .

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: cell projection; cytoplasm; focal adhesion; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome

Molecular Function: protein binding; transcription cofactor activity; zinc ion binding

Biological Process: cell adhesion; negative regulation of B cell receptor signaling pathway; negative regulation of cell adhesion; protein complex assembly; regulation of cell adhesion mediated by integrin; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent