GNB2 blocking peptide

GNB2 Blocking Peptide

Cat. Num. AAA9627067

• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: GNB2; GNB2 Blocking Peptide; G protein beta 2 subunit; G protein subunit beta 2; G protein subunit beta-2; GBB2_HUMAN; Gnb2; Gnb2l1; Guanine nucleotide binding protein beta 2 subunit; Guanine nucleotide binding protein G I G S G T beta 2 subunit 2; Guanine nucleotide binding protein G protein beta polypeptide 2; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; OTTHUMP00000174601; OTTHUMP00000174602; RACK1; Receptor for activated C kinase; Receptor of activated protein kinase C 1; Signal transducing guanine nucleotide binding regulatory protein beta; Transducin beta chain 2; GNB2 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for GNB2 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GNB2 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 20357529
• NCBI GeneID: 2783
• NCBI Accession #: NP_005264.2
• NCBI GenBank Nucleotide #: NM_005273.3
• UniProt Accession #: P62879; P11016; P54312; B3KPU1
• Molecular Weight: 37 kDa
• NCBI Official Full Name: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), beta polypeptide 2
• NCBI Official Symbol: GNB2
• NCBI Protein Information: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; G protein, beta-2 subunit; g protein subunit beta-2; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 2; sign
• UniProt Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
• UniProt Gene Name: GNB2
• UniProt Entry Name: GBB2_HUMAN

NCBI Description

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

Uniprot Description

G-beta 2: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family.

Protein type: G protein, heterotrimeric beta; G protein; G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: extracellular space; focal adhesion; lysosomal membrane; membrane; myelin sheath; perinuclear region of cytoplasm; plasma membrane; protein complex; vesicle

Molecular Function: calcium channel regulator activity; GTPase activity; GTPase binding; protein binding; protein complex binding; signal transducer activity

Biological Process: energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; synaptic transmission