HES5 blocking peptide

HES5 Peptide

Cat. Num. AAA153939

• Gene Names: HES5; bHLHb38
• Applications: Blocking (BL)
• Synonyms: HES5; HES5 Peptide; Hairy and enhancer of split 5; hes family bHLH transcription factor 5; bHLHb38 ; hes family bHLH transcription factor; HES5 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 166

• Applicable Applications for HES5 blocking peptide: Blocking (BL)
• Application Notes: HES5 peptide is used for blocking the activity of HES5 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 19 amino acid peptide near the amino terminus of human HES5.
• Preparation and Storage: Store HES5 peptide at -20 degree C, stable for one year.

Western Blot (WB)

(Western blot analysis of HES5 in Raji cell lysate with HES5 antibody at 1 μg/ml (A) the absence and (B) the presence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 58219048
• NCBI GeneID: 388585
• NCBI Accession #: NP_001010926
• NCBI GenBank Nucleotide #: NM_001010926.3
• UniProt Accession #: Q5TA89; B9DI85
• Molecular Weight: 18,226 Da
• NCBI Official Full Name: transcription factor HES-5
• NCBI Official Synonym Full Names: hes family bHLH transcription factor 5
• NCBI Official Symbol: HES5
• NCBI Official Synonym Symbols: bHLHb38
• NCBI Protein Information: transcription factor HES-5; hairy and enhancer of split 5; class B basic helix-loop-helix protein 38
• UniProt Protein Name: Transcription factor HES-5
• Protein Family: Transcription factor
• UniProt Gene Name: HES5
• UniProt Synonym Gene Names: BHLHB38; bHLHb38
• UniProt Entry Name: HES5_HUMAN

NCBI Description

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]

Uniprot Description

HES5: Transcriptional repressor of genes that require a bHLH protein for their transcription.

Protein type: Cell development/differentiation; Transcription regulation

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: nucleoplasm

Molecular Function: protein dimerization activity; double-stranded DNA binding; chromatin binding; transcription factor binding

Biological Process: neural tube development; radial glial cell differentiation in the forebrain; regulation of myelination; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; cell maturation; positive regulation of JAK-STAT cascade; auditory receptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of neurogenesis; astrocyte differentiation; regulation of cell differentiation; positive regulation of cell proliferation; chondrocyte differentiation; protein complex assembly; oligodendrocyte development; cell adhesion; positive regulation of Notch signaling pathway; positive regulation of BMP signaling pathway; Notch signaling pathway; smoothened signaling pathway; camera-type eye development; auditory receptor cell fate determination; transcription, DNA-dependent; myelination in the central nervous system; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; telencephalon development; glial cell fate commitment; cartilage development; negative regulation of astrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; brain development