FIR blocking peptide

FIR (P364) Peptide

Cat. Num. AAA3001836

• Gene Names: FARP2; FIR; FRG; PLEKHC3
• Applications: Blocking
• Purity: Synthetic peptide FIR (P364). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: FIR; FIR (P364) Peptide; 60 kDa poly(U)-binding-splicing factor; FBP-interacting repressor; FLJ31379; fuse-binding protein-interacting repressor; Poly(U)-binding-splicing factor PUF60; poly-U binding splicing factor PUF60; PUF60; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1; Ro-binding protein 1; RoBP1; RoBPI; siah binding protein 1; Siah-binding protein 1; Siah-BP1; SIAHBP1; FIR blocking peptide

• Specificity: This peptide can be used with studies using MBS3001835 FIR (P364) pAb.
• Purity/Purification: Synthetic peptide FIR (P364). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1054

• Applicable Applications for FIR blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for FIR blocking peptide

Activation of FUSE, the far-upstream element, is required for the proper expression of the mammalian gene c-myc. The binding of FBP (FUSE-binding protein) to FUSE is necessary for c-myc expression. The FBP interacting repressor, FIR, binds to the central DNA-binding domain of FBP and can serve as an overriding negative regulator of c-myc promoter activity. FIR interacts with the TFIIH complex, which is a multifunctional, multisubunit RNA polymerase II transcription factor that interacts with several DNA-binding transactivators. FIR blocks activator-dependent, but not basal transcription through TFIIH. FIR shares identity with seven in absentia (siah) binding protein 1. FIR is expressed in spleen, thymus, prostate, small intestine, colon, and peripheral blood leukocytes, and with relatively higher levels of expression in testis and ovary.

NCBI and Uniprot Product Information

• NCBI GI #: 7662310
• NCBI GeneID: 9855
• NCBI Accession #: NP_055623.1
• NCBI GenBank Nucleotide #: NP_055623.1
• UniProt Accession #: O94887
• NCBI Official Full Name: FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform a
• NCBI Official Synonym Full Names: FERM, ARH/RhoGEF and pleckstrin domain protein 2
• NCBI Official Symbol: FARP2
• NCBI Official Synonym Symbols: FIR; FRG; PLEKHC3
• NCBI Protein Information: FERM, ARHGEF and pleckstrin domain-containing protein 2
• UniProt Protein Name: FERM, RhoGEF and pleckstrin domain-containing protein 2
• UniProt Gene Name: FARP2
• UniProt Synonym Gene Names: KIAA0793; PLEKHC3; FIR
• UniProt Entry Name: FARP2_HUMAN

Uniprot Description

FARP2: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cytoskeleton; extrinsic to membrane; cytoplasm; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; cytoskeletal protein binding

Biological Process: axon guidance; regulation of integrin activation; actin cytoskeleton reorganization; Rac protein signal transduction; osteoclast differentiation; cell adhesion; neuron remodeling