Western Blot (WB)
(Western blot analysis on HuvEc cell lysate using FIR Antibody)
anti-Human, Mouse FIR Antibody | anti-FIR antibody
FIR Antibody
Gene Names
FARP2; FIR; FRG; PLEKHC3
Reactivity
Human, Mouse
Applications
Western Blot
Purity
Immunogen affinity purified
Synonyms
FIR; FIR Antibody; FERM; RhoGEF and pleckstrin domain protein 2; FGD1-related Cdc42-GEF; FRG; PLEKHC3; anti-FIR antibody
Reactivity
Human, Mouse
Specificity
FIR Antibody detects endogenous levels of FIR
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
647
Applicable Applications for anti-FIR antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
A synthesized peptide derived from human FIR
Preparation and Storage
Store at-20 degree C for 1 year
Western Blot (WB)
(Western blot analysis on HuvEc cell lysate using FIR Antibody)
Western Blot (WB)
(Western blot analysis on HuvEc cell lysate using FIR Antibody)
Related Product Information for anti-FIR antibody
Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor.Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. 2 isoforms of the human protein are produced by alternative splicing.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
119kDa
NCBI Official Full Name
FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform b
NCBI Official Synonym Full Names
FERM, ARH/RhoGEF and pleckstrin domain protein 2
NCBI Official Symbol
FARP2
NCBI Official Synonym Symbols
FIR; FRG; PLEKHC3
NCBI Protein Information
FERM, ARHGEF and pleckstrin domain-containing protein 2
UniProt Protein Name
FERM, ARHGEF and pleckstrin domain-containing protein 2
UniProt Gene Name
FARP2
UniProt Synonym Gene Names
KIAA0793; PLEKHC3; FIR; PH domain-containing family C member 3
Uniprot Description
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion ().
Research Articles on FIR
Similar Products
Product Notes
The FIR farp2 (Catalog #AAA8510955) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The FIR Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FIR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the FIR farp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FIR, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
