DSTYK blocking peptide

DSTYK Blocking Peptide (N-Term)

• Gene Names: DSTYK; RIP5; RIPK5; CAKUT1; DustyPK; HDCMD38P
• Synonyms: DSTYK; DSTYK Blocking Peptide (N-Term); Dual serine/threonine and tyrosine protein kinase; Dusty protein kinase; Dusty PK; RIP-homologous kinase; Receptor-interacting serine/threonine-protein kinase 5; Sugen kinase 496; SgK496; KIAA0472; RIP5; RIPK5; SGK496; DSTYK blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 256-270 of HUMAN DSTYK
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 929

• Cellular Location: Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction. Note: Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia.
• Tissue Location: Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DSTYK blocking peptide

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.

NCBI and Uniprot Product Information

• NCBI GI #: 296434486
• NCBI GeneID: 25778
• UniProt Accession #: Q6XUX3; O75060; Q17R94; Q5RKT0; Q6IN87; Q6P997; Q86Y03; Q9P1S5; B7ZL64
• Molecular Weight: 20,769 Da
• NCBI Official Full Name: Dual serine/threonine and tyrosine protein kinase
• NCBI Official Synonym Full Names: dual serine/threonine and tyrosine protein kinase
• NCBI Official Symbol: DSTYK
• NCBI Official Synonym Symbols: RIP5; RIPK5; CAKUT1; DustyPK; HDCMD38P
• NCBI Protein Information: dual serine/threonine and tyrosine protein kinase
• UniProt Protein Name: Dual serine/threonine and tyrosine protein kinase
• Protein Family: Dual serine/threonine and tyrosine protein kinase
• UniProt Gene Name: DSTYK
• UniProt Synonym Gene Names: KIAA0472; RIP5; RIPK5; SGK496; Dusty PK; SgK496
• UniProt Entry Name: DUSTY_HUMAN

NCBI Description

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

DSTYK: a serine/threonine protein kinase of the 'Other-Unique' family, most closely related to kinases of the TKL family including IRAK and RIPK. Overexpression induces apoptotic cell death. The caspase inhibitor crmA apparently blocks DNA fragmentation but not apoptosis, suggesting that SgK496 may induce both caspase-dependent apoptosis and caspase-independent cell death. Four alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.12.1; Kinase, protein; Other group; Other-Unique family

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytosol

Molecular Function: protein serine/threonine kinase activity

Biological Process: positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of kinase activity

Disease: Congenital Anomalies Of Kidney And Urinary Tract, Susceptibility To