Rabbit anti-Rat DSTYK Polyclonal Antibody | anti-DSTYK antibody

DSTYK Antibody (N-Term)

Cat. Num. AAA9216828

• Gene Names: DSTYK; RIP5; RIPK5; CAKUT1; DustyPK; HDCMD38P
• Reactivity: Rat
• Applications: Western Blot
• Synonyms: DSTYK; Polyclonal Antibody; DSTYK Antibody (N-Term); Purified Rabbit Polyclonal Antibody (Pab); Dual serine/threonine and tyrosine protein kinase; Dusty protein kinase; Dusty PK; RIP-homologous kinase; Receptor-interacting serine/threonine-protein kinase 5; Sugen kinase 496; SgK496; KIAA0472; RIP5; RIPK5; SGK496; anti-DSTYK antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This DSTYK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 256-290 amino acids from human DSTYK.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 929

• Applicable Applications for anti-DSTYK antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Anti-DSTYK Antibody (N-Term)at 1:2000 dilution + rat brain lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 105 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-DSTYK antibody

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.

Product Categories/Family for anti-DSTYK antibody

Cell Biology; Signal transduction

References

Peng J.,et al.Biochim. Biophys. Acta 1759:562-572(2006). Zhao Z.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases. Gregory S.G.,et al.Nature 441:315-321(2006). Seki N.,et al.DNA Res. 4:345-349(1997). Zha J.,et al.Biochem. Biophys. Res. Commun. 319:298-303(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 40806179
• NCBI GeneID: 25778
• NCBI Accession #: NP_056190.1
• NCBI GenBank Nucleotide #: NM_015375.2
• UniProt Accession #: Q6XUX3; O75060; Q17R94; Q5RKT0; Q6IN87; Q6P997; Q86Y03; Q9P1S5; B7ZL64
• Molecular Weight: 105206
• NCBI Official Full Name: dual serine/threonine and tyrosine protein kinase isoform 1
• NCBI Official Synonym Full Names: dual serine/threonine and tyrosine protein kinase
• NCBI Official Symbol: DSTYK
• NCBI Official Synonym Symbols: RIP5; RIPK5; CAKUT1; DustyPK; HDCMD38P
• NCBI Protein Information: dual serine/threonine and tyrosine protein kinase
• UniProt Protein Name: Dual serine/threonine and tyrosine protein kinase
• Protein Family: Dual serine/threonine and tyrosine protein kinase
• UniProt Gene Name: DSTYK
• UniProt Synonym Gene Names: KIAA0472; RIP5; RIPK5; SGK496; Dusty PK; SgK496
• UniProt Entry Name: DUSTY_HUMAN

NCBI Description

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

DSTYK: a serine/threonine protein kinase of the 'Other-Unique' family, most closely related to kinases of the TKL family including IRAK and RIPK. Overexpression induces apoptotic cell death. The caspase inhibitor crmA apparently blocks DNA fragmentation but not apoptosis, suggesting that SgK496 may induce both caspase-dependent apoptosis and caspase-independent cell death. Four alternatively spliced isoforms have been described.

Protein type: Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.12.1; Motility/polarity/chemotaxis; Other group; Other-Unique family

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: basolateral plasma membrane; apical plasma membrane; cytoplasm; cell junction

Molecular Function: protein serine/threonine kinase activity; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of kinase activity; positive regulation of fibroblast growth factor receptor signaling pathway

Disease: Congenital Anomalies Of Kidney And Urinary Tract, Susceptibility To