CREB3L1 blocking peptide

CREB3L1 Antibody (C-term) Blocking Peptide

• Gene Names: CREB3L1; OASIS
• Synonyms: CREB3L1; CREB3L1 Antibody (C-term) Blocking Peptide; Cyclic AMP-responsive element-binding protein 3-like protein 1; cAMP-responsive element-binding protein 3-like protein 1; Old astrocyte specifically-induced substance; OASIS; Processed cyclic AMP-responsive element-binding protein 3-like protein 1; CREB3L1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human CREB3L1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 519

• Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
• Tissue Location: Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CREB3L1 blocking peptide

Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 16418355
• NCBI GeneID: 90993
• NCBI Accession #: NP_443086
• NCBI GenBank Nucleotide #: NM_052854.3
• UniProt Accession #: Q96BA8; Q8N2D5; Q96CP0
• Molecular Weight: 47,783 Da
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 3-like protein 1
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 3 like 1
• NCBI Official Symbol: CREB3L1
• NCBI Official Synonym Symbols: OASIS
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 3-like protein 1
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 1
• Protein Family: Cyclic AMP-responsive element-binding protein 3-like protein
• UniProt Gene Name: CREB3L1
• UniProt Synonym Gene Names: OASIS; cAMP-responsive element-binding protein 3-like protein 1; OASIS
• UniProt Entry Name: CR3L1_HUMAN

NCBI Description

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

Uniprot Description

CREB3L1: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: endoplasmic reticulum; nucleus

Molecular Function: chromatin binding; protein binding

Biological Process: osteoblast differentiation; unfolded protein response