Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
Rabbit DNMT3A-K44 Polyclonal Antibody | anti-DNMT3A-K44 antibody
DiMethyl-DNMT3A-K44 pAb
Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
Immunofluorescence (IF)
(Immunofluorescence-DiMethyl-DNMT3A-K44 pAb)
NCBI and Uniprot Product Information
NCBI Description
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]
Uniprot Description
DNMT3A: a DNA methyltransferase required for genome wide de novo methylation and essential for development. DNA methylation is coordinated with methylation of histones. Prefers CpG methylation to CpA, CpT, and CpC methylation. Methylates CpG sites at a rate much slower than DNMT1, but greater than DNMT3b. Methylation is coordinated with methylation of histones. Binds the ZNF238 transcriptional repressor. Interacts with SETDB1 and DNMT1. Can co-localize with heterochromatin protein (HP1 ) and methyl-CpG binding protein (MeCBP). Associates with HDAC1 through its ADD-type zinc-finger. Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Protein type: Methyltransferase, DNA; EC 2.1.1.37; Methyltransferase; Amino Acid Metabolism - cysteine and methionine
Cellular Component: nucleoplasm; XY body; heterochromatin; euchromatin; nuclear matrix; cytoplasm; nuclear heterochromatin; nucleus; chromosome, pericentric region
Molecular Function: transferase activity; DNA (cytosine-5-)-methyltransferase activity; methyltransferase activity; identical protein binding; protein binding; DNA binding; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; unmethylated CpG binding; metal ion binding; chromatin binding
Biological Process: methylation; genetic imprinting; maintenance of DNA methylation; transcription, DNA-dependent; DNA methylation during gametogenesis; S-adenosylhomocysteine metabolic process; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; cytosine methylation within a CG sequence; methylation-dependent chromatin silencing; regulation of transcription, DNA-dependent; DNA methylation; S-adenosylmethioninamine metabolic process; spermatogenesis; DNA methylation during embryonic development; DNA methylation on cytosine
Research Articles on DNMT3A-K44
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Product Notes
The DNMT3A-K44 dnmt3a (Catalog #AAA9140673) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DiMethyl-DNMT3A-K44 pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DNMT3A-K44 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF). IF: 1:50-1:200. Researchers should empirically determine the suitability of the DNMT3A-K44 dnmt3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DNMT3A-K44, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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