Western Blot (WB)
(Western Blot analysis of CREB3L1 expression in transfected 293T cell line by CREB3L1 polyclonal antibody. Lane 1: CREB3L1 transfected lysate (57.09kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human OASIS Polyclonal Antibody | anti-CREB3L1 antibody
OASIS (Cyclic AMP-responsive Element-binding Protein 3-like Protein 1, cAMP-responsive Element-binding Protein 3-like Protein 1, Old Astrocyte Specifically-induced Substance, Processed Cyclic AMP-responsive Element-binding Protein 3-like Protein 1, CREB3L
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Immunofluorescence: 10ug/ml
Western Blot (WB)
(Western Blot analysis of CREB3L1 expression in transfected 293T cell line by CREB3L1 polyclonal antibody. Lane 1: CREB3L1 transfected lysate (57.09kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of CREB3L1 expression in transfected 293T cell line by CREB3L1 polyclonal antibody. Lane 1: CREB3L1 transfected lysate (57.09kD). Lane 2: Non-transfected lysate.)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to CREB3L1 on HeLa cell. [antibody concentration 10ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to CREB3L1 on HeLa cell. [antibody concentration 10ug/ml].)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]
Uniprot Description
Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE
By similarity. Ref.1
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein Ref.1 Ref.4. Processed cyclic AMP-responsive element-binding protein 3-like protein 1: Nucleus. Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. Ref.1 Ref.4
Tissue specificity: Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain. Ref.1
Post-translational modification: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
Sequence similarities: Belongs to the bZIP family. ATF subfamily.Contains 1 bZIP (basic-leucine zipper) domain.
Sequence caution: The sequence BAC11681.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on CREB3L1
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Product Notes
The CREB3L1 creb3l1 (Catalog #AAA646736) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The OASIS (Cyclic AMP-responsive Element-binding Protein 3-like Protein 1, cAMP-responsive Element-binding Protein 3-like Protein 1, Old Astrocyte Specifically-induced Substance, Processed Cyclic AMP-responsive Element-binding Protein 3-like Protein 1, CREB3L reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's OASIS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the CREB3L1 creb3l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MDAVLEPFPA DRLFPGSSFL DLGDLNESDF LNNAHFPEHL DHFTENMEDF SNDLFSSFFD DPVLDEKSPL LDMELDSPTP GIQAEHSYSL SGDSAPQSPL VPIKMEDTTQ DAEHGAWALG HKLCSIMVKQ EQSPELPVDP LAAPSAMAAA AAMATTPLLG LSPLSRLPIP HQAPGEMTQL PVIKAEPLEV NQFLKVTPED LVQMPPTPPS SHGSDSDGSQ SPRSLPPSSP VRPMARSSTA ISTSPLLTAP HKLQGTSGPL LLTEEEKRTL IAEGYPIPTK LPLTKAEEKA LKRVRRKIKN KISAQESRRK KKEYVECLEK KVETFTSENN ELWKKVETLE NANRTLLQQL QKLQTLVTNK ISRPYKMAAT QTGTCLMVAA LCFVLVLGSL VPCLPEFSSG SQTVKEDPLA ADGVYTASQM PSRSLLFYDD GAGLWEDGRS TLLPMEPPDG WEINPGGPAE QRPRDHLQHD HLDSTHETTK YLSEAWPKDG GNGTSPDFSH SKEWFHDRDL GPNTTIKLS. It is sometimes possible for the material contained within the vial of "OASIS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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