Western Blot (WB)
(Anti- GFRA1 antibody, MBS177489, Western blottingAll lanes: Anti GFRA1 (MBS177489) at 0.5ug/mlWB: Recombinant Human GFRA1 Protein 0.5ngPredicted bind size: 39KDObserved bind size: 39KD )
Rabbit GDNF family receptor alpha-1 Polyclonal Antibody | anti-GFRA1 antibody
Anti-GFRA1 Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human
Western Blot (WB)
(Anti- GFRA1 antibody, MBS177489, Western blottingAll lanes: Anti GFRA1 (MBS177489) at 0.5ug/mlWB: Recombinant Human GFRA1 Protein 0.5ngPredicted bind size: 39KDObserved bind size: 39KD )
Western Blot (WB)
(Anti- GFRA1 antibody, MBS177489, Western blottingAll lanes: Anti GFRA1 (MBS177489) at 0.5ug/mlWB: Recombinant Human GFRA1 Protein 0.5ngPredicted bind size: 39KDObserved bind size: 39KD )
Immunohistochemistry (IHC)
(Anti- GFRA1 antibody, MBS177489, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- GFRA1 antibody, MBS177489, IHC(P)IHC(P): Human Lung Cancer Tissue )
Western Blot (WB)
(Anti- GFRA1 antibody, MBS177489, Western blottingAll lanes: Anti GFRA1 (MBS177489) at 0.5ug/mlWB: Human Placenta Tissue Lysate at 50ugPredicted bind size: 51KDObserved bind size: 51KD )
Western Blot (WB)
(Anti- GFRA1 antibody, MBS177489, Western blottingAll lanes: Anti GFRA1 (MBS177489) at 0.5ug/mlWB: Human Placenta Tissue Lysate at 50ugPredicted bind size: 51KDObserved bind size: 51KD )
Background: GDNF family receptor alpha-1 (GFRalpha1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.
NCBI and Uniprot Product Information
NCBI Description
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009]
Uniprot Description
GFRA1: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Receptor, misc.
Chromosomal Location of Human Ortholog: 10q26.11
Cellular Component: extrinsic to membrane; plasma membrane
Molecular Function: receptor binding; glial cell line-derived neurotrophic factor receptor activity
Biological Process: axon guidance; cell surface receptor linked signal transduction
Research Articles on GFRA1
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Product Notes
The GFRA1 gfra1 (Catalog #AAA177489) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GFRA1 Antibody reacts with Human. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's GDNF family receptor alpha-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC-P). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human. Researchers should empirically determine the suitability of the GFRA1 gfra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GDNF family receptor alpha-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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