BAG2 blocking peptide

BAG2 Peptide

Cat. Num. AAA3231194

• Gene Names: BAG2; BAG-2; dJ417I1.2
• Applications: Immunohistochemistry, Western Blot
• Synonyms: BAG2; BAG2 Peptide; BAG2 blocking peptide

• Form/Format: Lyophilized powder
• Sequence Length: 211

• Applicable Applications for BAG2 blocking peptide: Immunohistochemistry (IHC), Western Blot (WB)
• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for BAG2 blocking peptide

This is a synthetic peptide designed for use in combination with anti-BAG2 antibody made

Target Description: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Product Categories/Family for BAG2 blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 4757834
• NCBI GeneID: 9532
• NCBI Accession #: NP_004273
• NCBI GenBank Nucleotide #: NM_004282
• UniProt Accession #: O95816
• Molecular Weight: 23kDa
• NCBI Official Full Name: BAG family molecular chaperone regulator 2
• NCBI Official Synonym Full Names: BCL2 associated athanogene 2
• NCBI Official Symbol: BAG2
• NCBI Official Synonym Symbols: BAG-2; dJ417I1.2
• NCBI Protein Information: BAG family molecular chaperone regulator 2
• UniProt Protein Name: BAG family molecular chaperone regulator 2
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: BAG2
• UniProt Synonym Gene Names: BAG-2
• UniProt Entry Name: BAG2_HUMAN

NCBI Description

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

Uniprot Description

BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 6p12.1-p11.2

Molecular Function: identical protein binding; protein binding; chaperone binding

Biological Process: protein folding; protein metabolic process