ATG9B blocking peptide

ATG9B Antibody (C-term) Blocking peptide

• Gene Names: ATG9B; SONE; APG9L2; NOS3AS
• Synonyms: ATG9B; ATG9B Antibody (C-term) Blocking peptide; Autophagy-related protein 9B; APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE; APG9L2; NOS3AS; ATG9B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of ATG9B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 924

• Cellular Location: Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note: Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1 and ATG13
• Tissue Location: Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ATG9B blocking peptide

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 74708555
• NCBI GeneID: 285973
• UniProt Accession #: Q674R7; Q6JRW5; Q8N8I8; A1A5D3
• Molecular Weight: 36,989 Da
• NCBI Official Full Name: Autophagy-related protein 9B
• NCBI Official Synonym Full Names: autophagy related 9B
• NCBI Official Symbol: ATG9B
• NCBI Official Synonym Symbols: SONE; APG9L2; NOS3AS
• NCBI Protein Information: autophagy-related protein 9B
• UniProt Protein Name: Autophagy-related protein 9B
• Protein Family: Autophagy-related protein
• UniProt Gene Name: ATG9B
• UniProt Synonym Gene Names: APG9L2; NOS3AS; Protein sONE
• UniProt Entry Name: ATG9B_HUMAN

NCBI Description

This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Uniprot Description

ATG9B: Plays a role in autophagy. Belongs to the ATG9 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Autophagy; Vesicle

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: autophagic vacuole

Biological Process: autophagic vacuole formation; mitochondrion degradation