Structure
PI-1840 Biochemical
PI-1840
Purity
>98% (HPLC)
Synonyms
PI-1840; PI1840; PI-1840 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Proteasome
Receptor
Chymotrypsin-likeproteasome
Chemical Name
Acetamide, N-(1-methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1, 2, 4-oxadiazol-5-yl]methyl]
SMILES
CCCC1=CC=C(C=C1)OCC(=O)N(CC2=NC(=NO2)C3=CN=CC=C3)C(C)C
Molecular Formula
C22H26N4O3
CAS Number
1401223-22-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PI-1840 biochemical
PI-1840 is a potent, selective, noncovalent, reversible inhibitor for proteasome chymotrypsin-like (CT-L) activity with IC50 of 27nM, shows no effect on trypsin-like and peptidylglutamyl peptide hydrolyzing activities (IC50>100uM); also displays 100-fold more selectivity for the constitutive proteasome over the immunoproteasome; induces the accumulation of proteasome substrates p27, Bax, and IkappaB-alpha, inhibits survival pathways and viability, and induces apoptosis in intact cancer cells, also sensitizes human cancer cells to the mdm2/p53 disruptor Nutlin; suppresses the growth in nude mice of human breast tumor xenografts.
Product Categories/Family for PI-1840 biochemical
References
1. Kazi A, et al. J Biol Chem. 2014 Apr 25; 289 (17):11906-15.
2. Ozcan S, et al. J Med Chem. 2013 May 23; 56 (10):3783-805.
2. Ozcan S, et al. J Med Chem. 2013 May 23; 56 (10):3783-805.
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Product Notes
The PI-1840 (Catalog #AAA3601674) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PI-1840, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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