Structure
USP7-IN-4, Inhibitor
USP7-IN-4
Purity
>98% (HPLC)
Synonyms
USP7-IN-4; R)-USP-IN-4; USP7 inhibitor 4; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
DUB
Receptor
DUB
Chemical Name
(R)-3-(4-(aminomethyl)phenyl)-6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-2, 6-dihydro-7H-pyrazolo[4, 3-d]pyrimidin-7-one
SMILES
O=C1C2=NN(C)C(C3=CC=C(CN)C=C3)=C2N=CN1CC4(O)CCN(C(C[C@H](C5=CC=CC=C5)C)=O)CC4
Molecular Formula
C29H34N6O3
CAS Number
2196243-57-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for USP7-IN-4, inhibitor
(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6nM in FP assays; also shows high potency in an alternative assay using the Ub-Rh110 substrate (IC50=1.5nM) and Kd of 2.0nM; displays high selectivuty against other DUBs, proteases and kinases; demonstrates highly potent target engagement in cells (EC50=49nM), with no off-target activity against USP47, causes nongenotoxic stabilization of p53 and decreased levels of MDM2 in HCT116 cells.
Product Categories/Family for USP7-IN-4, inhibitor
References
1. Gavory G, et al. Nat Chem Biol. 2018 Feb; 14 (2):118-125.
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Product Notes
The USP7-IN-4 (Catalog #AAA3603500) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "USP7-IN-4, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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