Structure
Celastrol Biochemical
Celastrol
Purity
>98% (HPLC)
Synonyms
Celastrol; Tripterin; Celastrol biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Proteasome
Receptor
20Sproteasome
Chemical Name
24, 25, 26-Trinoroleana-1(10), 3, 5, 7-tetraen-29-oic acid, 3-hydroxy-9, 13-dimethyl-2-oxo-, (9.beta., 13.alpha., 14.beta., 20.alpha.)
SMILES
CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
Molecular Formula
C29H38O4
CAS Number
34157-83-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Celastrol biochemical
Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5uM; also inhibits 26S proteasome in intact androgen-independent PC-3 and androgen-dependent LNCaP prostate cancer cells at 1-5uM, induces apoptotic cell death, and accumulates ubiquitinated proteins and natural proteasome substrates, IkappaB-alpha, Bax, and p27, and/or suppression of AR protein expression; promotes significant tumor growth inhibition and massive apoptosis induction in vivo.
Product Categories/Family for Celastrol biochemical
References
1. Yang H, et al. Cancer Res. 2006 May 1; 66 (9):4758-65.
2. Yadav VR, et al. J Mol Med (Berl). 2010 Dec; 88 (12):1243-53.
3. Chen M, et al. Mol Cancer Res. 2009 Dec; 7 (12):1946-53.
4. Ge P, et al. Neurol Res. 2010 Feb; 32 (1):94-100.
2. Yadav VR, et al. J Mol Med (Berl). 2010 Dec; 88 (12):1243-53.
3. Chen M, et al. Mol Cancer Res. 2009 Dec; 7 (12):1946-53.
4. Ge P, et al. Neurol Res. 2010 Feb; 32 (1):94-100.
Similar Products
Product Notes
The Celastrol (Catalog #AAA3604157) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Celastrol, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
