Structure
Serdemetan, Inhibitor
Serdemetan
Purity
>98% (HPLC)
Synonyms
Serdemetan; JNJ 26854165; JNJ26854165; JNJ-26854165; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
MDM2-p53
Receptor
HDM2; Mdm2; p53
Chemical Name
1, 4-Benzenediamine, N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl
SMILES
C1(NCCC2=CNC3=C2C=CC=C3)=CC=C(NC4=CC=NC=C4)C=C1
Molecular Formula
C21H20N4
CAS Number
881202-45-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Serdemetan, inhibitor
Serdemetan (JNJ 26854165) is a novel anticancer agent that inhibits the function of the E3 ligase HDM2, dose-dependently inhibits proliferation in both wild-type and mutant p53 cell lines with IC50 of 0.25-3uM; induces p53-mediated apoptosis in acute leukemia cells with wild-type p53, accelerates the proteasome-mediated degradation of p21 and antagonizes the transcriptional induction of p21 by p53, induces S-phase delay and upregulates E2F1 expression in p53 mutant cells; demonstrates radiosensitizing activity in vitro and in tumor xenografts. Lung Cancer Phase 1 Discontinued
Product Categories/Family for Serdemetan, inhibitor
References
1. Kojima K, et al. Mol Cancer Ther. 2010 Sep; 9 (9):2545-57.
2. Tabernero J, et al. Clin Cancer Res. 2011 Oct 1; 17 (19):6313-21.
3. Chargari C, et al. Cancer Lett. 2011 Dec 22; 312 (2):209-18.
4. Jones RJ, et al. J Pharmacol Exp Ther. 2013 Sep; 346 (3):381-92.
2. Tabernero J, et al. Clin Cancer Res. 2011 Oct 1; 17 (19):6313-21.
3. Chargari C, et al. Cancer Lett. 2011 Dec 22; 312 (2):209-18.
4. Jones RJ, et al. J Pharmacol Exp Ther. 2013 Sep; 346 (3):381-92.
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Product Notes
The Serdemetan (Catalog #AAA3606385) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Serdemetan, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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