Structure
Rpn11 inhibitor 35, Inhibitor
Rpn11 inhibitor 35
Purity
>98% (HPLC)
Synonyms
Rpn11 inhibitor 35; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=55.67mg/mL (88.53mM)
Target
Proteasome
Receptor
Proteasome
Chemical Name
8, 8'-disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide)
SMILES
C1=CC2=CC(=CN=C2C(=C1)SSC3=CC=CC4=CC(=CN=C43)C(=O)NCCC5=NC=CS5)C(=O)NCCC6=NC=CS6
Molecular Formula
C30H24N6O2S4
CAS Number
2084868-04-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Rpn11 inhibitor 35, inhibitor
Rpn11 inhibitor 35 is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400nM, 100-fold selectivity over Csn5 and 10-fold selectivity over AMSH; inhibits 293T and A549 cells proliferation with IC50 of 2.1 and 3.8uM, respectively.
Product Categories/Family for Rpn11 inhibitor 35, inhibitor
References
1. Perez C, et al. J Med Chem. 2017 Feb 23; 60 (4):1343-1361.
2. Li J, et al. Nat Chem Biol. 2017 May; 13 (5):486-493.
2. Li J, et al. Nat Chem Biol. 2017 May; 13 (5):486-493.
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Product Notes
The Rpn11 inhibitor 35 (Catalog #AAA3603249) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Rpn11 inhibitor 35, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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