Structure
Branebrutinib Biochemical
Branebrutinib
Purity
>98%
Synonyms
Branebrutinib; BMS-986195; 4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2; 3-dimethyl-1H-indole-7-carboxamide; Branebrutinib biochemical
Specificity
A potent inhibitor of BTK
Purity/Purification
>98%
Form/Format
White to off-White Solid Powder
Solubilities
~35mg/ml in DMSO
Molecular Formula
C??H??FN?O?
InChi
InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18-17(19)11(2)12(3)23-18/h9; 13; 23H; 5; 7-8; 10H2; 1-3H3; (H2; 22; 27)(H; 24; 26)/t13-/m0/s1
InChi Key
VJPPLCNBDLZIFG-ZDUSSCGKSA-N
SMILES
CC#CC(=O)NC1CCCN(C1)C2=C(C=C(C3=C2C(=C(N3)C)C)C(=O)N)F
CAS Number
1912445-55-6
MDL Number
MFCD31631584
PubChem CID
121293929
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Structure
Structure
Related Product Information for Branebrutinib biochemical
Branebrutinib is a potent covalent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor tyrosine kinase. It is a member of the Tec family of kinases and is essential for B cell receptor (BCR) mediated signaling. Branebrutinib inhibits BTK with IC50 values of 0.1nM, 0.9nM, 1.5nM and 5nM for BTK, TEC, BMX and TXK respectively. It inactivates BTK in the human whole blood assay rapidly at a rate of 3.5 × 10-4nM-1min-1. Branebrutinib inhibits signaling and functional end points, including calcium flux (IC50 = 7nM), production of cytokines, proliferation, and surface expression of the costimulatory molecule CD86 (IC50 values <1nM) in B cells stimulated through the B cell receptor.
Product Categories/Family for Branebrutinib biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/121293929
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Product Notes
The Branebrutinib (Catalog #AAA8400441) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Branebrutinib, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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