Structure
Amuvatinib Biochemical
Amuvatinib
Purity
>98% (HPLC)
Synonyms
Amuvatinib; MP-470; MP 470; MP470; HPK-56; HPK56; Amuvatinib biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
c-Kit
Receptor
c-Kit (D816H); FLT3 (D835Y); PDGFRalpha (V561D)
Chemical Name
1-Piperazinecarbothioamide, N-(1, 3-benzodioxol-5-ylmethyl)-4-benzofuro[3, 2-d]pyrimidin-4-yl
SMILES
S=C(N1CCN(C2=C(OC3=CC=CC=C34)C4=NC=N2)CC1)NCC5=CC=C(OCO6)C6=C5
Molecular Formula
C23H21N5O3S
CAS Number
850879-09-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Amuvatinib biochemical
A novel RTK inhibitor that effectively inhibits c-Kit, PDGFRalpha and Flt3 with IC50 of 10nM, 40nM and 81nM, respectively; also inhibits several mutants of c-Kit and Axl; inhibits prostate cancer cell proliferation (IC50=4-8uM), promotes cell cycle arrest and apoptosis; completely inhibites phosphorylation of the HER members (HER1, 2, 3), binding of PI3K regulatory unit p85 to HER3 and downstream Akt activity in combination with Erlotinib; exhibits synergistic effect in LNCaP mouse xenograft model. Lung Cancer Phase 2 Discontinued
Product Categories/Family for Amuvatinib biochemical
References
1. Mahadevan D, et al. Oncogene. 2007 Jun 7; 26 (27):3909-19.
2. Qi W, et al. BMC Cancer. 2009 May 11; 9:142.
4. Bearss DJ, et al. US Patent, US/2008/0226747.
2. Qi W, et al. BMC Cancer. 2009 May 11; 9:142.
4. Bearss DJ, et al. US Patent, US/2008/0226747.
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Product Notes
The Amuvatinib (Catalog #AAA3606179) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Amuvatinib, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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