Structure
Avapritinib, Inhibitor
Avapritinib
Purity
>98% (HPLC)
Synonyms
Avapritinib; BLU-285; BLU285; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 65mg/mL
Water: Insoluble
Ethanol: 3mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Water: Insoluble
Ethanol: 3mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
c-Kit
Receptor
KITD816V; PDGFRalphaD842V
Chemical Name
(1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2, 1-f][1, 2, 4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine
SMILES
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1
Molecular Formula
C26H27FN10
CAS Number
1703793-34-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Avapritinib, inhibitor
Avapritinib (BLU-285) is a potent and highly selective inhibitor of mutant KIT and PDGFRalpha with IC50 of 0.6, 0.27 and 0.24nM for KIT del557-558, KIT D816V and PDGFRA D842V, respectively; displays weak inhibition against WT KIT with IC50 of 73nM, >150-fold more potent on KIT D816V than several important kinase antitargets such as VEGFR2, SRC and FLT3; inhibits other well-characterized disease-driving KIT mutants both in vitro and in vivo in preclinical models, demonstrates marked activity in patients with diseases associated with KIT and PDGFRA (GIST) activation loop mutations. Gastric Cancer Phase 1 Clinical
Product Categories/Family for Avapritinib, inhibitor
References
1. Cancer Discov. 2017 Dec 12. doi: 10.1158/2159-8290.
2. Evans EK, et al. Sci Transl Med. 2017 Nov 1; 9 (414). pii: eaao1690.
3. Cancer Discov. 2018 Jan; 8 (1):OF20. doi: 10.1158/2159-8290.
2. Evans EK, et al. Sci Transl Med. 2017 Nov 1; 9 (414). pii: eaao1690.
3. Cancer Discov. 2018 Jan; 8 (1):OF20. doi: 10.1158/2159-8290.
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Product Notes
The Avapritinib (Catalog #AAA3602603) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Avapritinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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