Structure
G1T38, Inhibitor
G1T38
Purity
>98% (HPLC)
Synonyms
G1T38; Lerociclib; G1T 38; inhibitor
Purity/Purification
>98% (HPLC)
Target
CDK
Receptor
CDK
Chemical Name
2'-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-7', 8'-dihydro-6'H-spiro[cyclohexane-1, 9'-pyrazino[1', 2':1, 5]pyrrolo[2, 3-d]pyrimidin]-6'-one
SMILES
CC(C)N1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6
Molecular Formula
C26H34N8O
CAS Number
1628256-23-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for G1T38, inhibitor
G1T38 (Lerociclib, G1T 38) is a novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1nM and 2nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively; shows weak inhibitory effect on CDK9/cyclin T (IC50=28nM) and CDK5/p35 (IC50=832nM), >1,000-fold selectivity over CDK1/2/7; decreases RB1 phosphorylation, causes G1 arrest, and inhibits cell proliferation in a variety of CDK4/6-dependent tumorigenic cell lines; demonstrates equivalent or improved tumor efficacy compared to palbociclib in an ER+ breast cancer xenograft model. Breast Cancer, Phase 2 Clinical
Product Categories/Family for G1T38, inhibitor
References
1. Bisi JE, et al. Oncotarget. 2017 Jun 27; 8 (26):42343-42358.
2. Stice JP, et al. Mol Cancer Res. 2017 Jun; 15 (6):660-669.
2. Stice JP, et al. Mol Cancer Res. 2017 Jun; 15 (6):660-669.
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Product Notes
The G1T38 (Catalog #AAA3602425) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "G1T38, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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