ADDA 5 hydrochloride, Inhibitor | ADDA5, inhibitor
ADDA 5 hydrochloride
Purity
98.00%
Synonyms
ADDA 5 hydrochloride; ADDA5; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 65mg/mL (160.10mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H36ClNO2
SMILES
OC(COCCC1(C2)CC3CC2CC(C3)C1)CN4CC5=C(C=CC=C5)CC4.[H]Cl
CAS Number
473268-46-1
Target & IC50
CcO, human glioma: ic50 18.93uM
CcO, bovine heart: ic50 31.82uM
CcO, bovine heart: ic50 31.82uM
In Vitro
ADDA 5 does not causes detectable toxicity at up to 80mg/kg in mice[1]. ADDA 5 (8mg/kg, i.p.) obviously suppresses the growth of tumor in mice.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for ADDA5, inhibitor
ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO). For purified CcO from human glioma and bovine heart, the IC50s are 18.93uM and 31.82uM, respectively.
References
Oliva CR, et al. Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells. J Biol Chem. 2016 Nov 11;291(46):24188-24199. Epub 2016 Sep 27.
Oliva CR, et al. Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells. J Biol Chem. 2016 Nov 11;291(46):24188-24199. Epub 2016 Sep 27.
Oliva CR, et al. Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells. J Biol Chem. 2016 Nov 11;291(46):24188-24199. Epub 2016 Sep 27.
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Product Notes
The ADDA5 (Catalog #AAA5754480) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ADDA 5 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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