Structure

Ilorasertib hydrochloride, Inhibitor

Ilorasertib hydrochloride

Purity

98.00%

Synonyms

Ilorasertib hydrochloride; ABT-348 hydrochloride; inhibitor

Ordering
Cat. Num. AAA5753319 For Research Use Only!

Purity/Purification

98.00%

Form/Format

Solid. Powder

Solubility

DMSO: 41.67mg/mL (79.37mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C25H22ClFN6O2S

SMILES

O=C(NC1=CC=CC(F)=C1)NC2=CC=C(C3=CSC4=C3C(N)=NC=C4C5=CN(CCO)N=C5)C=C2.[H]Cl

CAS Number

1847485-91-9

Target & IC50

Aurora C: ic50 1nM
Aurora B: ic50 7nM
Aurora B (Y156H): ic50 12nM
Aurora A: ic50 120nM
PDGFRalpha: ic50 11nM
PDGFRbeta: ic50 13nM
VEGFR1: ic50 1nM
VEGFR2: ic50 2nM
VEGFR3: ic50 43nM
FLT3: ic50 1nM
CSF-1R: ic50 3nM
c-KIT: ic50 20nM

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Related Product Information for Ilorasertib hydrochloride, inhibitor

Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1nM, 7nM, 120nM). It also suppresses RET tyrosine kinase, PDGFRbeta, and Flt1 (IC50s: 7nM, 3nM, and 32nM).

Product Categories/Family for Ilorasertib hydrochloride, inhibitor

Cell Cycle/Checkpoint; Aurora Kinase; Chromatin/Epigenetic

References

Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.
Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.

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Product Notes

The Ilorasertib hydrochloride (Catalog #AAA5753319) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ilorasertib hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Ilorasertib hydrochloride, Inhibitor