Structure

Forodesine hydrochloride, Inhibitor

Forodesine hydrochloride

Purity

98.00%

Synonyms

Forodesine hydrochloride; BCX-1777 hydrochloride; Immucillin-H hydrochloride; inhibitor

Ordering
Cat. Num. AAA5753139 For Research Use Only!

Purity/Purification

98.00%

Form/Format

Solid. Powder

Solubility

H2O: 16.67mg/mL (55.07mM) Need ultrasonic
DMSO: 16.67mg/mL (55.07mM) Need ultrasonic
DMF: <1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C11H15ClN4O4

SMILES

O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1.Cl

CAS Number

284490-13-7

Target & IC50

Human PNP: ic50 1.19nM
Mouse PNP: ic50 0.48nM
Rat PNP: ic50 1.24nM
Monkey PNP: ic50 0.66nM
Dog PNP: ic50 1.57nM

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Related Product Information for Forodesine hydrochloride, inhibitor

Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels. Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57nM for human, mouse, rat, monkey and dog PNP.

References

Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.
Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.
Bantia S, et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent. Int Immunopharmacol. 2001 Jun;1(6):1199-210.
Bantia S, et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent. Int Immunopharmacol. 2001 Jun;1(6):1199-210.

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Product Notes

The Forodesine hydrochloride (Catalog #AAA5753139) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Forodesine hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Forodesine hydrochloride, Inhibitor