Structure
DMCM hydrochloride, Inhibitor | DMCM, inhibitor
DMCM hydrochloride
Purity
98.00%
Synonyms
DMCM hydrochloride; DMCM; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
H2O: 25mg/mL (71.27mM) Need ultrasonic
DMSO: 10mg/mL (28.51mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
DMSO: 10mg/mL (28.51mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H19ClN2O4
SMILES
O=C(C1=C(CC)C2=C(C=N1)NC3=C2C=C(OC)C(OC)=C3)OC.[H]Cl
CAS Number
1215833-62-7
Target & IC50
GABAA alpha1 receptor: ic50 10nM (ki)
GABAA alpha2 receptor: ic50 13nM (ki)
GABAA alpha3receptor: ic50 7.5nM (ki)
GABAA alpha5 receptor: ic50 2.2nM (ki)
GABAA alpha2 receptor: ic50 13nM (ki)
GABAA alpha3receptor: ic50 7.5nM (ki)
GABAA alpha5 receptor: ic50 2.2nM (ki)
In Vitro
DMCM has strong convulsive, convulsive and anxiolytic effects in the body. DMCM (20mg/kg; moderate anti-anxiety effect in group 2I77 mice.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for DMCM, inhibitor
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA zaerxep3 receptor subtypes. For sp1, sp2, sp3 and sp5 receptors, their Kis were 10nM, 13nM, 7.5nM, 2.2nM
Product Categories/Family for DMCM, inhibitor
References
Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47(24):5829-32.
Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47(24):5829-32.
Leppa E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48(4):469-78.
Leppa E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48(4):469-78.
Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47(24):5829-32.
Leppa E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48(4):469-78.
Leppa E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48(4):469-78.
Similar Products
Product Notes
The DMCM (Catalog #AAA5753028) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DMCM hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
