Mouse ATP-binding cassette sub-family A member 1 ELISA Kit | Abca1 elisa kit

Mouse ATP-binding cassette sub-family A member 1 ELISA Kit

Cat. Num. AAA2882568

• Gene Names: Abca1; Abc1; ABC-1
• Reactivity: Mouse
• Synonyms: ATP-binding cassette sub-family A member 1; Mouse ATP-binding cassette sub-family A member 1 ELISA Kit; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Abca1; Abc1; Abca1 elisa kit

• Reactivity: Mouse
• Sequence Length: 2261

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.089 ng/mL
• Intra-Assay CV: <=8.1%
• Inter-Assay CV: <=10.2%
• Recovery: 87%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 90568038
• NCBI GeneID: 11303
• NCBI Accession #: NP_038482.3
• NCBI GenBank Nucleotide #: NM_013454.3
• UniProt Accession #: P41233; B1AWZ8
• Molecular Weight: 253,912 Da
• NCBI Official Full Name: ATP-binding cassette sub-family A member 1
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family A (ABC1), member 1
• NCBI Official Symbol: Abca1
• NCBI Official Synonym Symbols: Abc1; ABC-1
• NCBI Protein Information: ATP-binding cassette sub-family A member 1
• UniProt Protein Name: ATP-binding cassette sub-family A member 1
• Protein Family: ABC transporter A family
• UniProt Gene Name: Abca1
• UniProt Synonym Gene Names: Abc1; ABC-1; ATP-binding cassette 1
• UniProt Entry Name: ABCA1_MOUSE

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Vesicle; Transporter, ABC family

Cellular Component: cell surface; endocytic vesicle; external side of plasma membrane; Golgi apparatus; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; lipid raft; membrane; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane

Molecular Function: anion transmembrane transporter activity; apolipoprotein A-I binding; apolipoprotein A-I receptor activity; apolipoprotein binding; ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; ATPase binding; cholesterol transporter activity; nucleotide binding; phospholipid transporter activity; protein binding; receptor binding; small GTPase binding; syntaxin binding; transporter activity

Biological Process: cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endosome transport; G-protein coupled receptor protein signaling pathway; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein biosynthetic process; lipoprotein metabolic process; lysosome organization and biogenesis; peptide secretion; phagocytosis, engulfment; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transport; platelet dense granule organization and biogenesis; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; regulation of Cdc42 protein signal transduction; response to high density lipoprotein stimulus; reverse cholesterol transport; transport