Ras-related protein Rab-17 (RAB17) Recombinant Protein | RAB17 recombinant protein

Recombinant Human Ras-related protein Rab-17 (RAB17)

Cat. Num. AAA1344859

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ras-related protein Rab-17 (RAB17); Recombinant Human Ras-related protein Rab-17 (RAB17); Ras-related protein Rab-17; RAB17 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-212aa; Full Length
• Sequence: MAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAAVALNKGPARQAKCCAH
• Sequence Length: 212

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for RAB17 recombinant protein

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration.

Product Categories/Family for RAB17 recombinant protein

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 11967981
• NCBI GeneID: 64284
• NCBI Accession #: NP_071894.1
• NCBI GenBank Nucleotide #: NM_022449.3
• UniProt Accession #: Q9H0T7; Q53QV6; Q6IA73; Q9BVU1; Q9H9U9
• Molecular Weight: 50.5 kDa
• NCBI Official Full Name: ras-related protein Rab-17
• NCBI Official Synonym Full Names: RAB17, member RAS oncogene family
• NCBI Official Symbol: RAB17
• NCBI Protein Information: ras-related protein Rab-17
• UniProt Protein Name: Ras-related protein Rab-17
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB17
• UniProt Entry Name: RAB17_HUMAN

NCBI Description

The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

Uniprot Description

RAB17: Might be involved in transcellular transport. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: recycling endosome; cell soma; endocytic vesicle; basolateral plasma membrane; recycling endosome membrane; apical plasma membrane; dendrite; early endosome; melanosome; plasma membrane; intracellular

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: intracellular protein transport; filopodium formation; regulation of synaptogenesis; metabolic process; regulation of endocytosis; regulation of dendrite development; cilium biogenesis; establishment of melanosome localization; regulation of filopodium formation; transcytosis; endocytic recycling; Rab protein signal transduction; melanosome transport; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor