Rabbit anti-Human Toso Polyclonal Antibody | anti-Toso antibody

Toso Antibody

Cat. Num. AAA9407382

• Gene Names: FCMR; TOSO; FAIM3
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: Toso; Polyclonal Antibody; Toso Antibody; Regulator of Fas-induced apoptosis; Fas apoptotic inhibitory molecule 3; FAIM3; anti-Toso antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 390

• Applicable Applications for anti-Toso antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 13 amino acid peptide from near the carboxy terminus of human Toso.
• Target Name: Toso
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Toso in human lung tissue lysate with Toso antibody at 1 ug/mL in either the (A) presence, or (B) absence of blocking peptide.)

Related Product Information for anti-Toso antibody

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

Product Categories/Family for anti-Toso antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4885641
• NCBI GeneID: 9214
• NCBI Accession #: NP_005440
• NCBI GenBank Nucleotide #: NM_005449.4
• Molecular Weight: 33,828 Da
• NCBI Official Full Name: fas apoptotic inhibitory molecule 3 isoform a
• NCBI Official Synonym Full Names: Fc fragment of IgM receptor
• NCBI Official Symbol: FCMR
• NCBI Official Synonym Symbols: TOSO; FAIM3
• NCBI Protein Information: fas apoptotic inhibitory molecule 3
• UniProt Protein Name: Fas apoptotic inhibitory molecule 3
• UniProt Gene Name: FCMR
• UniProt Entry Name: FAIM3_HUMAN

NCBI Description

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

Uniprot Description

FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis