Western Blot (WB)
(FAIM3 polyclonal antibody. Western Blot analysis of FAIM3 expression in human liver.)
Mouse anti-Human FAIM3 Polyclonal Antibody | anti-FAIM3 antibody
FAIM3 (Fas Apoptotic Inhibitory Molecule 3, Regulator of Fas-induced Apoptosis Toso, TOSO)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(FAIM3 polyclonal antibody. Western Blot analysis of FAIM3 expression in human liver.)
Western Blot (WB)
(FAIM3 polyclonal antibody. Western Blot analysis of FAIM3 expression in human liver.)
Western Blot (WB)
(FAIM3 polyclonal antibody. Western Blot analysis of FAIM3 expression in human spleen.)
Western Blot (WB)
(FAIM3 polyclonal antibody. Western Blot analysis of FAIM3 expression in human spleen.)
Western Blot (WB)
(Western Blot analysis of FAIM3 expression in transfected 293T cell line by FAIM3 polyclonal antibody. Lane 1: FAIM3 transfected lysate (42.9kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of FAIM3 expression in transfected 293T cell line by FAIM3 polyclonal antibody. Lane 1: FAIM3 transfected lysate (42.9kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
Uniprot Description
Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. Ref.1
Subcellular location: Isoform 1: Membrane; Single-pass membrane protein Ref.2. Isoform 3: Secreted. Note: Detected in the serum. Ref.2
Tissue specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells. Ref.1 Ref.2
Induction: By T-cell activation. Ref.1
Domain: The Ig-like domain is required for the anti-apoptotic ability.
Miscellaneous: 'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.
Sequence similarities: Contains 1 Ig-like (immunoglobulin-like) domain.
Research Articles on FAIM3
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Product Notes
The FAIM3 faim3 (Catalog #AAA648161) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FAIM3 (Fas Apoptotic Inhibitory Molecule 3, Regulator of Fas-induced Apoptosis Toso, TOSO) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FAIM3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the FAIM3 faim3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MDFWLWPLYF LPVSGALRIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR EMAGSGTCGT VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG VYACGAGMNT DRGKTQKVTL NVHSEYEPSW EEQPMPETPK WFHLPYLFQM PAYASSSKFV TRVTTPAQRG KVPPVHHSSP TTQITHRPRV SRASSVAGDK PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD YGSQSGREGQ GFHILIPTIL GLFLLALLGL VVKRAVERRK ALSRRARRLA VRMRALESSQ RPRGSPRPRS QNNIYSACPR RARGADAAGT GEAPVPGPGA PLPPAPLQVS ESPWLHAPSL KTSCEYVSLY HQPAAMMEDS DSDDYINVPA. It is sometimes possible for the material contained within the vial of "FAIM3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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