Human High mobility group protein HMGI-C (HMGA2) ELISA Kit | HMGA2 elisa kit

Human High mobility group protein HMGI-C (HMGA2) ELISA Kit

Cat. Num. AAA9329886

• Gene Names: HMGA2; BABL; LIPO; HMGIC; HMGI-C; STQTL9
• Reactivity: Human
• Synonyms: High mobility group protein HMGI-C (HMGA2); Human High mobility group protein HMGI-C (HMGA2) ELISA Kit; high mobility group AT-hook 2; BABL; HMGI-C; HMGIC; LIPO; STQTL9; High-mobility group protein HMGI-C|high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGA2 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Human Body Fluids, Tissue Homogenates, Secretions Or Feces Samples
• Assay Type: Quantitative Sandwich
• Detection Range: 3.12 ng/ml-100 ng/ml
• Sensitivity: 1.0 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for HMGA2 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of HMG20A (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 4504431
• NCBI GeneID: 8091
• NCBI Accession #: NP_003474.1
• NCBI GenBank Nucleotide #: NM_003483.4
• UniProt Accession #: P52926; Q1M182
• Molecular Weight: 11,832 Da
• NCBI Official Full Name: high mobility group protein HMGI-C isoform a
• NCBI Official Synonym Full Names: high mobility group AT-hook 2
• NCBI Official Symbol: HMGA2
• NCBI Official Synonym Symbols: BABL; LIPO; HMGIC; HMGI-C; STQTL9
• NCBI Protein Information: high mobility group protein HMGI-C; High-mobility group protein HMGI-C; high mobility group AT-hook protein 2; high-mobility group (nonhistone chromosomal) protein isoform I-C
• UniProt Protein Name: High mobility group protein HMGI-C
• Protein Family: High mobility group protein
• UniProt Gene Name: HMGA2
• UniProt Synonym Gene Names: HMGIC
• UniProt Entry Name: HMGA2_HUMAN

NCBI Description

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nucleoplasm; nuclear chromosome; nucleus

Molecular Function: protein binding; nucleosomal DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA binding; AT DNA binding; DNA-dependent protein kinase activity; 5'-deoxyribose-5-phosphate lyase activity; SMAD binding; transcription factor binding; DNA bending activity

Biological Process: fat cell differentiation; establishment and/or maintenance of chromatin architecture; positive regulation of apoptosis; multicellular organismal development; positive regulation of transcription, DNA-dependent; mesodermal cell differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; base-excision repair; regulation of growth; chondrocyte differentiation; mitosis; negative regulation of retroviral genome replication; transcription, DNA-dependent; response to virus; heterochromatin formation; DNA damage response, detection of DNA damage; stem cell differentiation; DNA catabolic process, endonucleolytic; negative regulation of DNA binding; chromosome condensation; mesenchymal cell differentiation; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; chromosome breakage; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Leiomyoma, Uterine