Rabbit anti-Human MPZL2 Polyclonal Antibody | anti-MPZL2 antibody

MPZL2 Antibody

Cat. Num. AAA7004002

• Gene Names: MPZL2; EVA; EVA1
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%,Protein G purified
• Synonyms: MPZL2; Polyclonal Antibody; MPZL2 Antibody; Myelin protein zero-like protein 2; Epithelial V-like antigen 1; EVA; EVA1; UNQ606/PRO1192; anti-MPZL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 215

• Applicable Applications for anti-MPZL2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Recombinant human Myelin protein zero-like protein 2 protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-168631
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer MBS7004002 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human Pancreatic Cancer MBS7004002 at dilution 1:100)

Related Product Information for anti-MPZL2 antibody

Mediates homophilic cell-cell adhesion.

NCBI and Uniprot Product Information

• NCBI GI #: 5032247
• NCBI GeneID: 10205
• NCBI Accession #: NP_005788.1
• NCBI GenBank Nucleotide #: NM_005797.3
• UniProt Accession #: O60487; A8K2R1
• Molecular Weight: 24,484 Da
• NCBI Official Full Name: myelin protein zero-like protein 2
• NCBI Official Synonym Full Names: myelin protein zero like 2
• NCBI Official Symbol: MPZL2
• NCBI Official Synonym Symbols: EVA; EVA1
• NCBI Protein Information: myelin protein zero-like protein 2
• UniProt Protein Name: Myelin protein zero-like protein 2
• Protein Family: Myelin protein zero-like protein
• UniProt Gene Name: MPZL2
• UniProt Synonym Gene Names: EVA; EVA1
• UniProt Entry Name: MPZL2_HUMAN

NCBI Description

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

MPZL2: Mediates homophilic cell-cell adhesion. Belongs to the myelin P0 protein family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: cytoskeleton; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: anatomical structure morphogenesis; homophilic cell adhesion; T cell differentiation in the thymus