Structure
LM22A-4, inhibitor
LM22A-4
Purity
98.00%
Synonyms
LM22A-4; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 29mg/mL (85.46mM)
H2O: 50mg/mL (147.34mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
H2O: 50mg/mL (147.34mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C15H21N3O6
SMILES
O=C(NCCO)c1cc(C(=O)NCCO)cc(C(=O)NCCO)c1
CAS Number
37988-18-4
Target & IC50
TrkB: ic50 47nM
Trk
Trk
In Vitro
treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequency[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for LM22A-4, inhibitor
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47nM in a fluorescence anisotropy assay)
Product Categories/Family for LM22A-4, inhibitor
References
Schmid D A, Yang T, Ogier M, et al. A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome[J]. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 2012, 32(5):1803-1810.
Schmid D A, Yang T, Ogier M, et al. A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome[J]. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 2012, 32(5):1803-1810.
Simmons D A, Belichenko N P, Yang T, et al. A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington"s Disease[J]. Journal of Neuroscience, 2013, 33(48):18712-18727.
Schmid D A, Yang T, Ogier M, et al. A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome[J]. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 2012, 32(5):1803-1810.
Simmons D A, Belichenko N P, Yang T, et al. A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington"s Disease[J]. Journal of Neuroscience, 2013, 33(48):18712-18727.
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Product Notes
The LM22A-4 (Catalog #AAA5758457) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LM22A-4, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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