Natural Killer Cell Receptor 2B4/SLAMF4/CD244 Recombinant Protein | 2B4/SLAMF4/CD244 recombinant protein

Recombinant Human Natural Killer Cell Receptor 2B4/SLAMF4/CD244 (C-Fc)

Cat. Num. AAA2569177

• Gene Names: CD244; 2B4; NAIL; Nmrk; NKR2B4; SLAMF4
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Natural Killer Cell Receptor 2B4/SLAMF4/CD244; Recombinant Human Natural Killer Cell Receptor 2B4/SLAMF4/CD244 (C-Fc); Natural killer cell receptor 2B4; NK cell activation-inducing ligand; NAIL; NKR2B4; h2B4; SLAM family member 4; SLAMF4; CD244; 2B4; 2B4/SLAMF4/CD244 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Cys22-Arg221

• Species: Human
• Tag: C-Fc
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Natural Killer Cell Receptor 2B4 is produced by our Mammalian expression system and the target gene encoding Cys22-Arg221 is expressed with a Fc tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

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Related Product Information for 2B4/SLAMF4/CD244 recombinant protein

Natural killer cell receptor 2B4 is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family.2B4 interacts with CD48, while other SLAM family proteins interact homophilically. Three additional splice variants of human 2B4 have deletions of the short region between the Ig-like domains, the second Ig-like domain, or a portion of the cytoplasmic tail.2B4 is expressed on all NK cells, gammadelta T cells, monocytes, some CD4+ and CD8+ T cells, and some dendritic cells. CD48 mediates 2B4+ cell interactions with nearly all hematopoietic cell types, including cells of the same type. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can either directly trigger inhibitory signaling or disrupt an inhibitory interaction, leading to cellular activation. The inhibitory effect is associated with the long form of 2B4, while the activation is associated with the short form. 2B4 can also induce signaling through CD48.

NCBI and Uniprot Product Information

• NCBI GI #: 47605541
• NCBI GeneID: 51744
• UniProt Accession #: Q9BZW8; Q5VYI2; Q5VYI6; Q5VYI7; Q96T47; Q9NQD2; Q9NQD3; Q9Y288
• Molecular Weight: 370
• NCBI Official Full Name: Natural killer cell receptor 2B4
• NCBI Official Synonym Full Names: CD244 molecule, natural killer cell receptor 2B4
• NCBI Official Symbol: CD244
• NCBI Official Synonym Symbols: 2B4; NAIL; Nmrk; NKR2B4; SLAMF4
• NCBI Protein Information: natural killer cell receptor 2B4; h2B4; SLAM family member 4; NK cell activation-inducing ligand; NK cell type I receptor protein 2B4; NK cell activation inducing ligand NAIL; signaling lymphocytic activation molecule 4
• UniProt Protein Name: Natural killer cell receptor 2B4
• UniProt Gene Name: CD244
• UniProt Synonym Gene Names: 2B4; NAIL; NKR2B4; h2B4; SLAMF4
• UniProt Entry Name: CD244_HUMAN

NCBI Description

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Description

CD244: Modulate other receptor-ligand interactions to enhance leukocyte activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: signal transduction; blood coagulation; leukocyte migration

Disease: Rheumatoid Arthritis