Human Receptor I For The Fc Region Of Immunoglobulin E (FceRI) ELISA Kit | FceRI elisa kit
Human Receptor I For The Fc Region Of Immunoglobulin E (FceRI) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
Uniprot Description
FcER1B: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Belongs to the MS4A family.
Protein type: Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q12-q13
Cellular Component: integral to plasma membrane; Fc-epsilon receptor I complex; plasma membrane; endosome; lipid raft; external side of plasma membrane
Molecular Function: phosphoprotein binding; IgE binding; SH2 domain binding; protein kinase binding; IgE receptor activity
Biological Process: phospholipase C activation; protein kinase C activation; innate immune response; positive regulation of mast cell degranulation; immune response; inflammatory response; cytokine secretion; regulation of release of sequestered calcium ion into cytosol
Disease: Ige Responsiveness, Atopic
Research Articles on FceRI
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Product Notes
The Human FceRI fceri (Catalog #AAA9312590) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9312590 ELISA Kit recognizes Human FceRI. It is sometimes possible for the material contained within the vial of "Receptor I For The Fc Region Of Immunoglobulin E (FceRI), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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