Rat Bone Morphogenetic Protein 1 ELISA Kit | BMP1 elisa kit

Rat Bone Morphogenetic Protein 1 ELISA Kit

Cat. Num. AAA722741

• Gene Names: BMP1; PCP; TLD; OI13; PCP2; PCOLC
• Reactivity: Rat
• Synonyms: Bone Morphogenetic Protein 1; Rat Bone Morphogenetic Protein 1 ELISA Kit; BMP1 elisa kit

• Reactivity: Rat

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 0.5-10ng/mL
• Sensitivity: 0.1ng/ml
• Highest Standards: 10ng/mL
• Concentration of Standards: Concentration of Standards
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Product Categories/Family for BMP1 elisa kit

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 5453579
• NCBI GeneID: 649
• NCBI Accession #: NP_006120.1
• NCBI GenBank Nucleotide #: NM_006129.4
• Molecular Weight: 92,655 Da
• NCBI Official Full Name: bone morphogenetic protein 1 isoform 3
• NCBI Official Synonym Full Names: bone morphogenetic protein 1
• NCBI Official Symbol: BMP1
• NCBI Official Synonym Symbols: PCP; TLD; OI13; PCP2; PCOLC
• NCBI Protein Information: bone morphogenetic protein 1; mammalian tolloid protein; procollagen C-proteinase 3; procollagen C-endopeptidase
• UniProt Protein Name: Bone morphogenetic protein 1
• Protein Family: Bone morphogenetic protein
• UniProt Gene Name: BMP1
• UniProt Synonym Gene Names: PCOLC; BMP-1; mTld; PCP
• UniProt Entry Name: BMP1_HUMAN

NCBI Description

This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]

Uniprot Description

BMP1: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Defects in BMP1 are a cause of autosomal recessive osteogenesis imperfecta (AR-OI). A connective tissue disorder characterized by bone fragility, progressively deforming bones, bowing of limbs due to multiple fractures, very short stature, a triangular face, severe scoliosis, and grayish sclera. AR-OI due to BMP1 mutations belongs to the group of osteogenesis imperfecta type III in the Sillence classification. Belongs to the peptidase M12A family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Protease; EC 3.4.24.19

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: Golgi apparatus; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; growth factor activity; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; cytokine activity; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; ossification; multicellular organismal development; lipoprotein metabolic process; cell differentiation; proteolysis; skeletal development; cartilage condensation

Disease: Osteogenesis Imperfecta, Type Xiii