Ihh blocking peptide

Ihh Blocking Peptide (C-term)

• Gene Names: Ihh; HHG-2
• Synonyms: Ihh; Ihh Blocking Peptide (C-term); Indian hedgehog protein; IHH; HHG-2; Indian hedgehog protein N-product; Indian hedgehog protein C-product; Ihh blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 397-410 of HUMAN Ihh
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 411

• Cellular Location: Indian hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note: The N-terminal peptide remains associated with the cell surface. Cell membrane.
• Tissue Location: In the embryo, detected in the developing gut, the growth zone of cartilage of developing long bones, epithelium and urogenital sinus. In the adult kidney, found in proximal convoluted and proximal straight tubule
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Ihh blocking peptide

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).

NCBI and Uniprot Product Information

• NCBI GI #: 6166227
• NCBI GeneID: 16147
• UniProt Accession #: P97812; Q61724
• Molecular Weight: 45,485 Da
• NCBI Official Full Name: Indian hedgehog protein
• NCBI Official Synonym Full Names: Indian hedgehog
• NCBI Official Symbol: Ihh
• NCBI Official Synonym Symbols: HHG-2
• NCBI Protein Information: indian hedgehog protein
• UniProt Protein Name: Indian hedgehog protein
• Protein Family: Indian hedgehog protein
• UniProt Gene Name: Ihh
• UniProt Synonym Gene Names: IHH
• UniProt Entry Name: IHH_MOUSE

Uniprot Description

IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in adult kidney and liver. Belongs to the hedgehog family.

Cellular Component: plasma membrane; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; patched binding; protein binding

Biological Process: bone resorption; camera-type eye development; cartilage development; cell differentiation; cell fate specification; cell maturation; embryonic camera-type eye morphogenesis; embryonic development; embryonic digestive tract morphogenesis; embryonic digit morphogenesis; embryonic pattern specification; heart looping; in utero embryonic development; morphogenesis of a branching structure; multicellular organism growth; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptosis; negative regulation of cell differentiation; negative regulation of eye pigmentation; negative regulation of immature T cell proliferation in the thymus; negative regulation of signal transduction; negative regulation of T cell differentiation in the thymus; neuron development; ossification; osteoblast differentiation; pancreas development; pattern specification process; patterning of blood vessels; positive regulation of alpha-beta T cell differentiation; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of collagen biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; positive regulation of T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; proteoglycan metabolic process; regulation of cell differentiation; regulation of growth; skeletal development; smooth muscle development; smoothened signaling pathway; vasculature development; vitelline membrane formation