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IHH recombinant protein
Recombinant Human Indian hedgehog protein(IHH)
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015]
Uniprot Description
IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in adult kidney and liver. Belongs to the hedgehog family.
Chromosomal Location of Human Ortholog: 2q33-q35
Cellular Component: extracellular space; plasma membrane; proteinaceous extracellular matrix
Molecular Function: calcium ion binding; patched binding; peptidase activity
Biological Process: bone resorption; cartilage development; cell fate specification; cell maturation; cell-cell signaling; embryonic camera-type eye morphogenesis; embryonic digestive tract morphogenesis; embryonic digit morphogenesis; embryonic pattern specification; heart looping; in utero embryonic development; intein-mediated protein splicing; maternal process involved in pregnancy; multicellular organism growth; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptosis; negative regulation of eye pigmentation; negative regulation of immature T cell proliferation in the thymus; negative regulation of signal transduction; negative regulation of T cell differentiation in the thymus; neuron development; osteoblast differentiation; pancreas development; patterning of blood vessels; positive regulation of alpha-beta T cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of collagen biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; positive regulation of T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; proteoglycan metabolic process; regulation of growth; response to estradiol stimulus; skeletal development; smooth muscle development; smoothened signaling pathway; vitelline membrane formation
Disease: Acrocapitofemoral Dysplasia; Brachydactyly, Type A1
Research Articles on IHH
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Product Notes
The IHH ihh (Catalog #AAA1466366) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 203-411aa; Partial. The amino acid sequence is listed below: CFPAGAQVRL ESGARVALSA VRPGDRVLAM GEDGSPTFSD VLIFLDREPH RLRAFQVIET QDPPRRLALT PAHLLFTADN HTEPAARFRA TFASHVQPGQ YVLVAGVPGL QPARVAAVST HVALGAYAPL TKHGTLVVED VVASCFAAVA DHHLAQLAFW PLRLFHSLAW GSWTPGEGVH WYPQLLYRLG RLLLEEGSFH PLGMSGAGS. It is sometimes possible for the material contained within the vial of "IHH, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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