Goat anti-Human Apolipoprotein C-I / APOC1 Polyclonal Antibody | anti-APOC1 antibody

Goat Polyclonal (IgG) to Human Apolipoprotein C-I / APOC1

Cat. Num. AAA242363

• Gene Names: APOC1; Apo-CI; ApoC-I
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: Apolipoprotein C-I / APOC1; Polyclonal Antibody; Goat Polyclonal (IgG) to Human Apolipoprotein C-I / APOC1; Anti-Apolipoprotein C-I / APOC1 Antibody IHC-plus; APOC1; Apo-c1; Apo-CI; Apo-CIB; ApoC-I; Apolipoprotein C-I; ApoC-IB; APOC1B; Apolipoprotein C1; Apolipoprotein CI; Human Apolipoprotein C-I; anti-APOC1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Apo C-I in plasma and lipoproteins. Does not cross-react with plasma Apo A-I, Apo A-II, Apo B-100, Apo C-II, Apo C-III and Apo-E.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7.2, 0.5 mM EDTA, 0.02% sodium azide, 40% glycerol.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 83

• Applicable Applications for anti-APOC1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:100 - 1:10000), IHC-P (5 ug/ml), WB (1:100 - 1:10000); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Native human Apo C-I.
• Immunogen Type: Purified protein
• Immunogen: Apolipoprotein C-I / APOC1 antibody was raised against native human Apo C-I.
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-APOC1 / Apolipoprotein CI antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-APOC1 antibody

Apolipoprotein (apo) C-I gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A copy of the apo C-I gene, apo C-I', is located 4 kb downstream in the same orientation, on the same chromosome. However, apo C-I' gene has no detectable mRNA product in any tissue, suggesting that it may be a pseudogene. The apoC-I gene is 4653 bases long and the apo C-I' is 4387 base pairs, and each contains four exons and 3 introns.

NCBI and Uniprot Product Information

• NCBI GI #: 4502157
• NCBI GeneID: 341
• NCBI Accession #: NP_001636.1
• NCBI GenBank Nucleotide #: NM_001645.3
• UniProt Accession #: P02654; Q6IB97; B2R526
• Molecular Weight: 9,332 Da
• NCBI Official Full Name: apolipoprotein C-I
• NCBI Official Synonym Full Names: apolipoprotein C-I
• NCBI Official Symbol: APOC1
• NCBI Official Synonym Symbols: Apo-CI; ApoC-I
• NCBI Protein Information: apolipoprotein C-I; apo-CIB; apoC-IB; apolipoprotein C1; apolipoprotein C-I variant I
• UniProt Protein Name: Apolipoprotein C-I
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOC1
• UniProt Synonym Gene Names: Apo-CI; ApoC-I
• UniProt Entry Name: APOC1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family.

Protein type: Inhibitor; Lipid-binding; Secreted, signal peptide; Secreted; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: chylomicron; endoplasmic reticulum

Molecular Function: phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding

Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; negative regulation of cholesterol transport; lipoprotein metabolic process; cholesterol efflux; triacylglycerol metabolic process; negative regulation of lipid catabolic process; phospholipid efflux; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; lipid metabolic process; negative regulation of lipid metabolic process; regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process