Rabbit anti-Human IHH Polyclonal Antibody | anti-IHH antibody

IHH Antibody (C-term)

Cat. Num. AAA9216769

• Gene Names: IHH; BDA1; HHG2
• Reactivity: Human
• Applications: Western Blot
• Synonyms: IHH; Polyclonal Antibody; IHH Antibody (C-term); Purified Rabbit Polyclonal Antibody (Pab); Indian hedgehog protein; HHG-2; Indian hedgehog protein N-product; Indian hedgehog protein C-product; anti-IHH antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This IHH antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 248-281 amino acids from the C-terminal region of human IHH.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 411

• Applicable Applications for anti-IHH antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-IHH Antibody (C-term) at 1:2000 dilutionLane 1: HL-60 whole cell lysatesLane 2: Jurkat whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 45 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-IHH antibody

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).

Product Categories/Family for anti-IHH antibody

Stem Cells

References

Tate G.,et al.J. Biochem. Mol. Biol. Biophys. 4:27-34(2000). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Marigo V.,et al.Genomics 28:44-51(1995). Chang D.T.,et al.Development 120:3339-3353(1994). Pepinsky R.B.,et al.J. Biol. Chem. 273:14037-14045(1998).

NCBI and Uniprot Product Information

• NCBI GI #: 119392086
• NCBI GeneID: 3549
• NCBI Accession #: NP_002172.2
• NCBI GenBank Nucleotide #: NM_002181.3
• UniProt Accession #: Q14623; O43322; Q8N4B9; B9EGM5
• Molecular Weight: 45251
• NCBI Official Full Name: indian hedgehog protein preproprotein
• NCBI Official Synonym Full Names: indian hedgehog
• NCBI Official Symbol: IHH
• NCBI Official Synonym Symbols: BDA1; HHG2
• NCBI Protein Information: indian hedgehog protein
• UniProt Protein Name: Indian hedgehog protein
• Protein Family: Indian hedgehog protein
• UniProt Gene Name: IHH
• UniProt Synonym Gene Names: IHH
• UniProt Entry Name: IHH_HUMAN

NCBI Description

This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015]

Uniprot Description

IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in adult kidney and liver. Belongs to the hedgehog family.

Chromosomal Location of Human Ortholog: 2q33-q35

Cellular Component: proteinaceous extracellular matrix; extracellular space; plasma membrane

Molecular Function: peptidase activity; patched binding; calcium ion binding

Biological Process: vitelline membrane formation; proteoglycan metabolic process; maternal process involved in pregnancy; cell maturation; positive regulation of collagen biosynthetic process; cell fate specification; embryonic pattern specification; response to estradiol stimulus; positive regulation of T cell differentiation in the thymus; smooth muscle development; cell-cell signaling; embryonic digestive tract morphogenesis; regulation of growth; positive regulation of mesenchymal cell proliferation; pancreas development; positive regulation of smoothened signaling pathway; heart looping; skeletal development; bone resorption; negative regulation of immature T cell proliferation in the thymus; smoothened signaling pathway; intein-mediated protein splicing; in utero embryonic development; multicellular organism growth; negative regulation of eye pigmentation; negative regulation of T cell differentiation in the thymus; negative regulation of signal transduction; patterning of blood vessels; osteoblast differentiation; positive regulation of chondrocyte differentiation; cartilage development; neuron development; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; positive regulation of alpha-beta T cell differentiation; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of alpha-beta T cell differentiation

Disease: Brachydactyly, Type A1; Acrocapitofemoral Dysplasia