RAI17 Blocking Peptide | ZMIZ1 blocking peptide

RAI17 Antibody (C-term) Blocking Peptide

• Gene Names: ZMIZ1; MIZ; RAI17; ZIMP10; hZIMP10; TRAFIP10
• Synonyms: RAI17; RAI17 Antibody (C-term) Blocking Peptide; Zinc finger MIZ domain-containing protein 1; PIAS-like protein Zimp10; Retinoic acid-induced protein 17; ZMIZ1; KIAA1224; ZIMP10; ZMIZ1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human RAI17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 1067

• Cellular Location: Nucleus speckle. Cytoplasm
• Tissue Location: Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ZMIZ1 blocking peptide

Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.

NCBI and Uniprot Product Information

• NCBI GI #: 56404979
• NCBI GeneID: 57178
• UniProt Accession #: Q9ULJ6; Q5JSH9; Q7Z7E6
• Molecular Weight: 107,270 Da
• NCBI Official Full Name: Zinc finger MIZ domain-containing protein 1
• NCBI Official Synonym Full Names: zinc finger MIZ-type containing 1
• NCBI Official Symbol: ZMIZ1
• NCBI Official Synonym Symbols: MIZ; RAI17; ZIMP10; hZIMP10; TRAFIP10
• NCBI Protein Information: zinc finger MIZ domain-containing protein 1
• UniProt Protein Name: Zinc finger MIZ domain-containing protein 1
• Protein Family: Zinc finger MIZ domain-containing protein
• UniProt Gene Name: ZMIZ1
• UniProt Synonym Gene Names: KIAA1224; RAI17; ZIMP10
• UniProt Entry Name: ZMIZ1_HUMAN

NCBI Description

This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]

Uniprot Description

RAI17: Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: intracellular membrane-bound organelle; nucleoplasm