DLG7 Blocking Peptide | DLGAP5 blocking peptide

DLG7 Antibody (N-term) Blocking Peptide

• Gene Names: DLGAP5; DLG7; HURP
• Synonyms: DLG7; DLG7 Antibody (N-term) Blocking Peptide; Disks large-associated protein 5; DAP-5; Discs large homolog 7; Disks large-associated protein DLG7; Hepatoma up-regulated protein; HURP; DLGAP5; KIAA0008; DLGAP5 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human DLG7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 846

• Cellular Location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note: Localizes to the spindle in mitotic cells Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells
• Tissue Location: Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DLGAP5 blocking peptide

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

NCBI and Uniprot Product Information

• NCBI GI #: 82592583
• NCBI GeneID: 9787
• UniProt Accession #: Q15398; Q86T11; Q8NG58; A8MTM6; B4DRM8
• Molecular Weight: 94,178 Da
• NCBI Official Full Name: Disks large-associated protein 5
• NCBI Official Synonym Full Names: DLG associated protein 5
• NCBI Official Symbol: DLGAP5
• NCBI Official Synonym Symbols: DLG7; HURP
• NCBI Protein Information: disks large-associated protein 5
• UniProt Protein Name: Disks large-associated protein 5
• Protein Family: Disks large-associated protein
• UniProt Gene Name: DLGAP5
• UniProt Synonym Gene Names: DLG7; KIAA0008; DAP-5; HURP
• UniProt Entry Name: DLGP5_HUMAN

Uniprot Description

DLG7: a cell cycle regulator that may play a role in carcinogenesis. Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. Required for chromosome congression and alignment. Stabilizes mitotic microtubules, promotes microtubule polymerization and controls spindle formation and dynamics Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Interacts with CDC2 and localizes to the spindle poles in mitotic cells. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Colocalizes with E-cadherin (CDH1) at sites of cell-cell contact in intestinal epithelial cells. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Two alternatively spliced isoforms have been described.

Protein type: Cell cycle regulation; Microtubule-binding

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: cytoplasm; microtubule organizing center; nucleus; spindle pole centrosome

Molecular Function: phosphoprotein phosphatase activity; protein binding