Rabbit LSP1 Polyclonal Antibody | anti-LSP1 antibody

Rabbit Polyclonal to Human LSP1

Cat. Num. AAA241915

• Gene Names: LSP1; WP34; pp52
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: LSP1; Polyclonal Antibody; Rabbit Polyclonal to Human LSP1; Anti-LSP1 Antibody (aa37-48) IHC-plus; 47 kDa actin-binding protein; 47 kDa actin binding protein; 52 kDa phosphoprotein; Leukocyte-specific protein 1; Lymphocyte-specific protein 1; Pp52; WP34; Human LSP1; anti-LSP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of human LSP1 protein independent of phosphorylation at ~52kD.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, BSA, 50% glycerol.
• Sequence Length: 339

• Applicable Applications for anti-LSP1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (1:100), WB (1:1000); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide (KLH coupled) corresponding to residues surrounding amino acid 37-48 of human LSP1.
• Immunogen Type: Synthetic peptide
• Immunogen: LSP1 antibody was raised against synthetic peptide (KLH coupled) corresponding to residues surrounding amino acid 37-48 of human LSP1.
• Antigen Modification: aa37-48
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-LSP1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)

NCBI and Uniprot Product Information

• NCBI GI #: 10880979
• NCBI GeneID: 4046
• NCBI Accession #: NP_002330.1
• NCBI GenBank Nucleotide #: NM_002339.2
• UniProt Accession #: P33241; Q16096; Q53H48; Q6FHM3; Q9BUY8; B3KPP1; B3KRR6; E9PBV6; E9PFP3
• Molecular Weight: 50,389 Da
• NCBI Official Full Name: lymphocyte-specific protein 1 isoform 1
• NCBI Official Synonym Full Names: lymphocyte-specific protein 1
• NCBI Official Symbol: LSP1
• NCBI Official Synonym Symbols: WP34; pp52
• NCBI Protein Information: lymphocyte-specific protein 1; 52 kDa phosphoprotein; 47 kDa actin binding protein; 47 kDa actin-binding protein; leukocyte-specific protein 1; lymphocyte-specific antigen WP34; leufactin (leukocyte F-actin binding protein); F-actin binding and cytoskeleton associated protein
• UniProt Protein Name: Lymphocyte-specific protein 1
• Protein Family: Lymphocyte-specific protein
• UniProt Gene Name: LSP1
• UniProt Synonym Gene Names: WP34; pp52
• UniProt Entry Name: LSP1_HUMAN

NCBI Description

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

LSP1: May play a role in mediating neutrophil activation and chemotaxis. Binds actin. Activated T-lymphocytes.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; plasma membrane; actin cytoskeleton

Molecular Function: signal transducer activity; actin binding

Biological Process: cellular defense response; cell motility; signal transduction; chemotaxis