TMIGD2 active protein

TMIGD2 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121548

• Gene Names: TMIGD2; CD28H; IGPR1; IGPR-1
• Purity: >85% as determined by Nu-PAGE
• Synonyms: TMIGD2; TMIGD2 Protein; Human; Recombinant (His Tag); Human IGPR-1/TMIGD2 Protein (His Tag); IGPR-1 Protein; IGPR1 Protein; TPC1 Protein; transmembrane and immunoglobulin domain containing 2; TMIGD2 active protein

• Host: HEK293 Cells
• Purity/Purification: >85% as determined by Nu-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gly150

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Leu 23
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human TMIGD2 (NP_653216.2)(Met1-Gly150) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Activity: 1.Measured by its binding ability in a functional ELISA. 2.Immobilized human TMIGD2 at 10ug/mL (100uL/well) can bind human HHLA2-Fc. The EC50 of human HHLA2-Fc is 0.3-3ug/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Testing Data

(Measured by its binding ability in a functional ELISA. Immobilized human TMIGD2 at 10 ug/mL (100 uL/well) can bind human HHLA2-Fc, the EC50 of human HHLA2-Fc is 0.3-3ug/mL.)

Related Product Information for TMIGD2 active protein

Background: The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent in mouse and rat genomes. The immunoglobulin domain of IGPR-1 was predicted to be Ig V (variable) fold and was found to be highly similar to the Ig domain of myelin-associated glycoprotein.

Product Categories/Family for TMIGD2 active protein

Cancer Drug Targets

References

Rahimi N, Rezazadeh K, Mahoney JE, Hartsough E, Meyer RD. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. Nusrat A, ed. Molecular Biology of the Cell. 2012;23(9):1646-1656.

NCBI and Uniprot Product Information

• NCBI GI #: 281306838
• NCBI GeneID: 126259
• NCBI Accession #: NP_653216.2
• NCBI GenBank Nucleotide #: NM_144615.2
• UniProt Accession #: Q96BF3; Q6UW59
• Molecular Weight: 30,319 Da
• NCBI Official Full Name: transmembrane and immunoglobulin domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: transmembrane and immunoglobulin domain containing 2
• NCBI Official Symbol: TMIGD2
• NCBI Official Synonym Symbols: CD28H; IGPR1; IGPR-1
• NCBI Protein Information: transmembrane and immunoglobulin domain-containing protein 2
• UniProt Protein Name: Transmembrane and immunoglobulin domain-containing protein 2
• Protein Family: Transmembrane and immunoglobulin domain-containing protein
• UniProt Gene Name: TMIGD2
• UniProt Synonym Gene Names: CD28H; IGPR1; IGPR-1
• UniProt Entry Name: TMIG2_HUMAN

Uniprot Description

IGPR-1: Plays a role in cell-cell interaction, cell migration, and angiogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; coreceptor activity

Biological Process: positive regulation of cytokine production; T cell costimulation; signal transduction; positive regulation of activated T cell proliferation