Goat MHC class I polypeptide-related sequence B ELISA Kit | MICB elisa kit

Goat MHC class I polypeptide-related sequence B ELISA Kit

Cat. Num. AAA748970

• Gene Names: MICB; PERB11.2
• Reactivity: Goat
• Synonyms: MHC class I polypeptide-related sequence B; Goat MHC class I polypeptide-related sequence B ELISA Kit; MICB elisa kit

• Reactivity: Goat

• Preparation and Storage: Store all reagents at 2-8 degree C

Product Categories/Family for MICB elisa kit

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 167857788
• NCBI GeneID: 4277
• NCBI Accession #: NP_005922.2
• NCBI GenBank Nucleotide #: NM_005931.3
• UniProt Accession #: Q29980; O14499; O14500; O19798; O19799; O19800; O19801; O19802; O19803; O78099; A6NP85; B0UZ10
• Molecular Weight: 42,646 Da
• NCBI Official Full Name: MHC class I polypeptide-related sequence B
• NCBI Official Synonym Full Names: MHC class I polypeptide-related sequence B
• NCBI Official Symbol: MICB
• NCBI Official Synonym Symbols: PERB11.2
• NCBI Protein Information: MHC class I polypeptide-related sequence B; MIC-B; MHC class I mic-B antigen; stress inducible class I homolog; MHC class I chain-related protein B; MHC class I-like molecule PERB11.2-IMX
• UniProt Protein Name: MHC class I polypeptide-related sequence B
• Protein Family: MHC class I polypeptide-related sequence
• UniProt Gene Name: MICB
• UniProt Synonym Gene Names: PERB11.2; MIC-B
• UniProt Entry Name: MICB_HUMAN

NCBI Description

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. [provided by RefSeq, Jul 2008]

Uniprot Description

MICB: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. The MICB*004 allele is associated with rheumatoid arthritis. Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk. Belongs to the MHC class I family. MIC subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cell surface; plasma membrane; integral to membrane

Molecular Function: beta-2-microglobulin binding; antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; regulation of immune response; response to retinoic acid; viral reproduction; response to heat; natural killer cell mediated cytotoxicity; cytolysis; immune response-activating cell surface receptor signaling pathway; negative regulation of defense response to virus by host; response to oxidative stress; gamma-delta T cell activation; T cell mediated cytotoxicity